103260-54-4

Upstream product

• 77344-70-8 1-(2-bromo-5-methylphenyl)ethanone 
• 90221-55-9 2-bromo-5-methylbenzaldehyde 
• 75-16-1 methylmagnesium bromide 
• 1048108-06-0 2-bromo-N-methoxy-N,5-dimethylbenzamide 

Downstream Products

• 90560-52-4 2-bromo-5-methyl-styrene 
• 77344-70-8 1-(2-bromo-5-methylphenyl)ethanone 
• 1378431-00-5 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[{[3-(1-{[(methyloxy)methyl]oxy}ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}(methylsulfonyl)amino]-1-benzofuran-3-carboxamide 
• 1378427-83-8 5-cyclopropyl-2-(4-fluorophenyl)-6-[{[(3S)-1-hydroxy-3-methyl-1,3-dihydro-2,1-benzoxaborol-5-yl]methyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide 
• 1378427-84-9 5-cyclopropyl-2-(4-fluorophenyl)-6-[{[(3R)-1-hydroxy-3-methyl-1,3-dihydro-2,1-benzoxaborol-5-yl]methyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide 
• 1378427-76-9 5-cyclopropyl-2-(4-fluorophenyl)-6-[[(1-hydroxy-3-methyl-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide 
• 1378430-98-8 6-[{[4-bromo-3-(1-{[(methyloxy)methyl]oxy}ethyl)phenyl]methyl}(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide 
• 1378430-97-7 1-bromo-4-(bromomethyl)-2-(1-{[(methyloxy)methyl]oxy}ethyl)benzene 
• 1378430-96-6 1-bromo-4-methyl-2-(1-{[(methyloxy)methyl]oxy}ethyl)benzene 

Relevant academic research and scientific papers

Preparation of isoindolinones via a palladium-catalyzed diamination

A Pd(II)-catalyzed cyclization using oxidative olefin diamination was developed for the preparation of isoindolinones from ortho-olefinic N-methoxybenzamides. Using the optimized reaction conditions, the desired products were obtained in up to 90% yield using NFSI as the oxidant. This reaction provides an efficient and direct access to isoindolinones with amine functionality, an important drug skeleton.