103261-28-5Relevant academic research and scientific papers
Nickel-catalyzed regioselective hydrocyanation of terminal alkynes by assistance of a tosyl group
Arai, Shigeru,Nakazawa, Koichi,Yang, Xiao-fei,Nishida, Atsushi
, p. 2482 - 2485 (2019)
Nickel-catalyzed regioselective hydrocyanation of terminal alkynes is described. A tosylamide functionality at the propargyl position was the most suitable group for controlling the regiochemistry for C–CN bond formation as well as rate enhancement. A gram-scale synthesis was achieved by minimizing the catalyst loading to 2 mol%. The major HCN adduct could be transformed to the corresponding indoline through construction of a benzylic quaternary carbon under iron catalysis.
Synthesis of 4-substituted 3,3-difluoropiperidines
Surmont, Riccardo,Verniest, Guido,Thuring, Jan Willem,Macdonald, Gregor,Deroose, Frederik,De Kimpe, Norbert
supporting information; experimental part, p. 929 - 932 (2010/07/02)
Synthetic strategies toward 4-substituted 3,3-difluoropiperidines were evaluated. 4-Alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines were synthesized via 1,4-addition of ethyl bromodifluoroacetate to 3-substituted acrylonitriles in the presence o
