103262-35-7

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-1-benzofuran-5-ylmethanol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure and potential biological activities make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
DHBM is also used in the synthesis of agrochemical compounds, contributing to the development of effective and environmentally friendly pesticides and other agricultural products.
Used in Fragrance and Flavor Industry:
2,3-Dihydro-1-benzofuran-5-ylmethanol is used as a raw material in the production of fragrances and flavors. Its unique chemical properties allow it to impart distinct and desirable scents and tastes to various consumer products.
Used in Organic Synthesis:
As a versatile building block, 2,3-dihydro-1-benzofuran-5-ylmethanol is widely used in organic synthesis for the preparation of a variety of chemical compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Biological Research:
Due to its potential anti-inflammatory and anticancer properties, DHBM is used in biological research to study its effects on various biological processes and to explore its potential as a therapeutic agent for various diseases.

InChI:InChI=1/C9H10O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-2,5,10H,3-4,6H2

Upstream product

• 55745-70-5 2,3-dihydro-benzofuran-5-carbaldehyde 
• 76429-73-7 2,3-dihydrobenzofuran-5-carboxylic acid 
• 496-16-2 2.3-dihydrobenzofuran 

Downstream Products

• 55745-68-1 (2,3-dihydrobenzo[b]furan-5-yl)methyl chloride 
• 196598-26-2 5-bromomethyl-2,3-dihydrobenzofuran 
• 1353585-35-9 3-(2,3-dihydro-benzofuran-5-ylmethyl)-1-(4-methoxy-benzyl)-6-methylsulfanyl-1H-[1,3,5]triazine-2,4-dione 

Relevant academic research and scientific papers

Benzopentaoxyheterocycle-benzimidazole salt compounds, and synthesis method and application thereof

The invention discloses benzopentaoxyheterocycle-benzimidazole salt compounds, and a synthesis method and an application thereof, and belongs to the technical field of medicinal chemistry. The structural formula of the benzopentaoxyheterocycle-benzimidazole salt compounds is shown in the description. In the formula, when X is O and Y is CH2, R and R are H, and R is a 2-naphthoylmethyl group, or R is CH3, R is H, and R is a 2-naphthoylmethyl group, a 4-bromobenzyl, a 2-naphthylmethyl group, a 4-methylbenzyl group or a 2-bromobenzyl group; when X is CH2 and Y is C-O, R and R are H, and R is a 2-naphthoylmethyl group, or R is CH3, R is H, and R is a 2-naphthoylmethyl group, or R is H, R is CH3, and R is a 2-naphthoylmethyl group or a 2-bromobenzylgroup; and when X is CH2 and Y is CH2, R is H, R is CH3, and R is a 2-naphthoylmethyl group or a 2-bromobenzyl group. Medicines prepared from the compounds of the invention and at least one pharmaceutically acceptable excipient, diluent or carrier can be used for tumor cancers.

Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers

A mild, efficient and rapid protocol was developed for the deprotection of alcoholic TBDMS ethers using a recyclable, eco-friendly highly sulphated cellulose sulphate acid catalyst in methanol. This acid catalyst selectively cleaves alcoholic TBDMS ethers in bis-TBDMS ethers containing both alcoholic and phenolic TBDMS ether moieties.

Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders

A compound having the following general fomula: wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydrocarbon or heterocyclic group; X is CHR4, NR4, O or S in which R4 is H or an optionally substituted hydrocarbon group; R5 is H, a halogen atom, C1-6 alkyl group, a C1-6 alkoxy group, a hydroxy group, a nitro group, a cyano group or an amino group wherein the C1-6 alkyl group, the C1-6 alkoxy group and the amino group may be substituted by 1 to 5 substituents, Y is C or N; ring B is an optionally substituted benzene ring; m = 1 to 4 and n = 0 to 2; L represents a leaving group such as a halogen atom, an alkylsulfonyl group, an alkylsulfonlyoxy group and arylsulfonyloxy group; or a salt thereof.

PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound of the formula wherein R1 is a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 nitrogen atom(s), which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle; X is an oxygen atom, a nitrogen atom optionally substituted by a hydrocarbon group having 1 to 5 carbon atom(s) or a sulfur atom optionally oxidized with 1 or 2 oxygen, Y is a bond or a C1-5 alkylene group, R2 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a C1-5 alkylthio group, (5) a carbocycle having 3 to 15 carbon atoms or (6) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s), provided that when Y is a bond, R2 is a carbocycle having 3 to 15 carbon atoms or a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s) and; one of R3 and R4 is a hydrogen atom or a group of the formula: -Z-R5 (Z is a bond or C1-10 alkylene group optionally having substituent(s) and R5 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a nitrile group, (5) a C1-5 alkoxy-carbonyl group, (6) a carboxyl group, (7) a carbamoyl group, (8) a (mono or di-C1-5 alkyl)carbamoyl group, (9) an amino group, (10) a (di or mono-C1-5 alkyl)amino group, (11) a (C1-5 alkoxy-carbonyl)amino group, (12) a C1-5 alkylthio group, (13) a carbocycle having 3 to 15 carbon atoms or (14) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s)); the other is a group of the formula: -Z-R5 (Z and R5 are as defined above); and R3 and R4 may form, together with the adjacent nitrogen atom, a heterocycle having a skeleton consisting of 3 to 15 atoms, which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle, wherein the above-mentioned heterocycle and a carbocycle having 3 to 15 carbon atoms are each optionally substituted by substituent(s) selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C7-16 aralkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6-14 aryl, C1-8 alkoxy, C1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-C1-5 alkyl)amino, (C1-5 alkoxy-carbonyl)amino, (C1-5 acyl)amino, (C1-5 acyl) (C1-5 alkyl)amino, C1-5 alkylthio, nitrile, nitro, C1-5 alkoxy-carbonyl, carboxyl, C1-5 alkyl-carbonyloxy, oxo, thioxo, C1-6 acyl group, sulfamoyl and (di or mono-C1-5 alkyl)sulfamoyl, or a salt thereof or a prodrug thereof have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the prophylaxis or treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis and the like, allergic diseases such as asthma, or disorders of male or female genital function and the like.

Tricyclic compounds, their production and use

A compound of the formula: STR1 wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydrocarbon or heterocyclic group; X is CHR4, NR4, O or S in which R4 is H or an optionally substituted hydrocarbon group; Y is C, CH or N; ring A is optionally substituted 5- to 7-membered ring; ring B is an optionally substituted benzene ring; and m is 1 to 4, or a salt thereof, a process for producing it, an intermediate for the production and a pharmaceutical composition comprising it are provided.