55745-68-1

Usage

Uses

Used in Pharmaceutical Research:
5-CHLOROMETHYL-2,3-DIHYDROBENZOFURAN is used as a chemical intermediate for the synthesis of various pharmaceutical drugs. Its unique structure and functional groups enable the development of new drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 5-CHLOROMETHYL-2,3-DIHYDROBENZOFURAN is employed as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and structural features allow for the formation of various chemical entities with different properties and applications.
Used in Chemical Industry:
5-CHLOROMETHYL-2,3-DIHYDROBENZOFURAN is utilized in the chemical industry for the production of specialty chemicals and intermediates. Its unique properties and reactivity make it a valuable component in the synthesis of various chemical products.
Used in Research and Development:
In research and development, 5-CHLOROMETHYL-2,3-DIHYDROBENZOFURAN serves as a valuable compound for exploring new chemical reactions and mechanisms. Its unique structure and reactivity provide opportunities for the discovery of novel synthetic routes and the development of innovative chemical processes.
Used in Academic Research:
5-CHLOROMETHYL-2,3-DIHYDROBENZOFURAN is employed in academic research to study the properties and behavior of heterocyclic compounds. Its unique structure and reactivity make it an interesting subject for investigations into the synthesis, properties, and applications of heterocyclic compounds in various fields.

Upstream product

• 103262-35-7 (2,3-dihydrobenzo[b]furan-5-yl)methanol 
• 124-63-0 methanesulfonyl chloride 
• 55745-70-5 2,3-dihydro-benzofuran-5-carbaldehyde 
• 496-16-2 2.3-dihydrobenzofuran 

Downstream Products

• 133099-04-4 darifenacin 

Relevant academic research and scientific papers

PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound of the formula wherein R1 is a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 nitrogen atom(s), which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle; X is an oxygen atom, a nitrogen atom optionally substituted by a hydrocarbon group having 1 to 5 carbon atom(s) or a sulfur atom optionally oxidized with 1 or 2 oxygen, Y is a bond or a C1-5 alkylene group, R2 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a C1-5 alkylthio group, (5) a carbocycle having 3 to 15 carbon atoms or (6) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s), provided that when Y is a bond, R2 is a carbocycle having 3 to 15 carbon atoms or a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s) and; one of R3 and R4 is a hydrogen atom or a group of the formula: -Z-R5 (Z is a bond or C1-10 alkylene group optionally having substituent(s) and R5 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a nitrile group, (5) a C1-5 alkoxy-carbonyl group, (6) a carboxyl group, (7) a carbamoyl group, (8) a (mono or di-C1-5 alkyl)carbamoyl group, (9) an amino group, (10) a (di or mono-C1-5 alkyl)amino group, (11) a (C1-5 alkoxy-carbonyl)amino group, (12) a C1-5 alkylthio group, (13) a carbocycle having 3 to 15 carbon atoms or (14) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s)); the other is a group of the formula: -Z-R5 (Z and R5 are as defined above); and R3 and R4 may form, together with the adjacent nitrogen atom, a heterocycle having a skeleton consisting of 3 to 15 atoms, which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle, wherein the above-mentioned heterocycle and a carbocycle having 3 to 15 carbon atoms are each optionally substituted by substituent(s) selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C7-16 aralkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6-14 aryl, C1-8 alkoxy, C1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-C1-5 alkyl)amino, (C1-5 alkoxy-carbonyl)amino, (C1-5 acyl)amino, (C1-5 acyl) (C1-5 alkyl)amino, C1-5 alkylthio, nitrile, nitro, C1-5 alkoxy-carbonyl, carboxyl, C1-5 alkyl-carbonyloxy, oxo, thioxo, C1-6 acyl group, sulfamoyl and (di or mono-C1-5 alkyl)sulfamoyl, or a salt thereof or a prodrug thereof have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the prophylaxis or treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis and the like, allergic diseases such as asthma, or disorders of male or female genital function and the like.