103281-31-8Relevant academic research and scientific papers
Sterically congested ester formation from α-substituted malononitrile and alcohol by an oxidative method using molecular oxygen
Hayashi, Yujiro,Li, Jing,Asano, Hirotaka,Sakamoto, Daisuke
, p. 675 - 677 (2018/11/23)
A metal-free oxidative esterification or thio-esterifica-tion of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.
Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists
Xia, Jun,Song, Jianfei,Zhen, Le,Zhang, Xiuling,Lei, Xiantao,Zheng, Lina,Wang, Qiujuan,Sun, Hongbin
supporting information; experimental part, p. 3894 - 3897 (2011/08/06)
A series of novel 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyric acid derivatives were synthesized and evaluated for their antagonistic activity for endothelin-1-induced contraction in rabbit aorta. Within this series of compounds, 2-[(4,6-dimet
