103319-02-4

Basic information

• Product Name: Cyclohexanone, 4-(4-pyridinyl)-
• CAS NO: 103319-02-4
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol File: 103319-02-4.mol

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-(4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(4-pyridinyl)-(103319-02-4)
• EPA Substance Registry System: Cyclohexanone, 4-(4-pyridinyl)-(103319-02-4)

Safety Data

• Hazardous Substances Data: 103319-02-4(Hazardous Substances Data)

Upstream product

• 117960-46-0 4-(4-pyridyl)cyclohexanone ethylene ketal 
• 70644-46-1 4-(3-cyclohexen-1-yl)pyridine 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 1120-87-2 4-bromopyridin 
• 103319-00-2 4-hydroxy-4-(4-pyridyl)cyclohexanone ethylene ketal 
• 26845-47-6 methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 19524-06-2 4-bromopyridine hydrochloride 
• 59137-44-9 3-carboxy-2-(pyridin-1-ium-1-yl)propanoate 
• 110-86-1 pyridine 

Downstream Products

• 1365153-66-7 N-Methyl-4-(pyridin-4-yl)cyclohexanamine 
• 1365563-49-0 (3R)-3-[(2-chlorobenzoyl)amino]-N-methyl-N-(4-pyridin-4-ylcyclohexyl)-2,3-dihydro-1H-indene-5-carboxylic acid amide 
• 103319-03-5 2-acetyl-4-(pyridin-4-yl)-cyclohexanone 
• 115883-26-6 2-propanoyl-4-(4-pyridyl)cyclohexanone 
• 115883-37-9 4-benzoyl-1-methyl-7-(4-pyridyl)5,6,7,8-tetrahydro-3(2H)isoquinolinone 
• 117960-64-2 2-ethylidene-4-(4-pyridyl)cyclohexanone 
• 117960-63-1 2-(1-hydroxyethyl)-4-(4-pyridyl)cyclohexanone 
• 117960-62-0 2-pentanoyl-4-(4-pyridyl)cyclohexanone 

Relevant articles and documents

Syntheses of 4-(Heteroaryl)cyclohexanones via Palladium-Catalyzed Ester α-Arylation and Decarboxylation

An alternative synthesis of 4-(heteroaryl)cyclohexanones is described featuring a palladium-catalyzed ester α-arylation followed by decarboxylation. The substrate scope is broad with a wide range of heteroaryl halides. In particular, the reaction robustness is demonstrated by the synthesis of >10 g of 4-(pyrazin-2-yl)cyclohexanone with 85% overall yield.

Practical and Regioselective Synthesis of C-4-Alkylated Pyridines

The direct position-selective C-4 alkylation of pyridines has been a long-standing challenge in heterocyclic chemistry, particularly from pyridine itself. Historically this has been addressed using prefunctionalized materials to avoid overalkylation and mixtures of regioisomers. This study reports the invention of a simple maleate-derived blocking group for pyridines that enables exquisite control for Minisci-type decarboxylative alkylation at C-4 that allows for inexpensive access to these valuable building blocks. The method is employed on a variety of different pyridines and carboxylic acid alkyl donors, is operationally simple and scalable, and is applied to access known structures in a rapid and inexpensive fashion. Finally, this work points to an interesting strategic departure for the use of Minisci chemistry at the earliest possible stage (native pyridine) rather than current dogma that almost exclusively employs Minisci chemistry as a late-stage functionalization technique.

Substituted Benzamide Compounds

Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.

Liquid phase oxidation of alkenes with nitrous oxide to carbonyl compounds

A variety of substrates including linear, cyclic, heterocyclic alkenes and their derivatives were tested in the liquid phase non-catalytic oxidation with nitrous oxide (N2O). The structure and composition of the alkenes have a significant effect on the reaction selectivity. With many alkenes, N 2O oxidation provides a selective way for the preparation of carbonyl compounds. The generation of carbene (or diazomethane) species is a remarkable feature of the oxidation of terminal alkenes.

Process for preparing 4-acetyl isoquinolinone compounds

This invention relates to a novel process for preparing 4-acetyl-1-methyl-7-pyridyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone characterized by condensing 2-acetyl-4-pyridyl cyclohexanone with acetoacetamide. This compound is useful as pharmaceuticals, parti

Cardiotonic Agents. 1-Methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinones and Related Compounds. Synthesis and Activity

A series of 1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series exerted a dose-dependent increase in myocardial contractility in the dog acute heart failure model, whereas they caused only slight changes in heart rate and blood pressure.Several derivatives, especially those with cyano, acetyl, and ethyl substituents at the 4-position, were more potent than milrinone, which was used as a reference. 4-Acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone (MS-857) is one of the most potent positive inotropic agents in this series.