115883-37-9

Upstream product

• 103318-83-8 4-cyano-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone 
• 103319-00-2 4-hydroxy-4-(4-pyridyl)cyclohexanone ethylene ketal 
• 103319-03-5 2-acetyl-4-(pyridin-4-yl)-cyclohexanone 
• 103319-01-3 4-(4-pyridyl)cyclohex-3-en-1-one ethylene ketal 
• 117960-46-0 4-(4-pyridyl)cyclohexanone ethylene ketal 
• 103319-02-4 4-(pyridin-4-yl)-cyclohexanone 
• 1120-87-2 4-bromopyridin 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Relevant academic research and scientific papers

Cardiotonic Agents. 1-Methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinones and Related Compounds. Synthesis and Activity

A series of 1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series exerted a dose-dependent increase in myocardial contractility in the dog acute heart failure model, whereas they caused only slight changes in heart rate and blood pressure.Several derivatives, especially those with cyano, acetyl, and ethyl substituents at the 4-position, were more potent than milrinone, which was used as a reference. 4-Acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone (MS-857) is one of the most potent positive inotropic agents in this series.

Isoquinoline derivatives

The isoquinoline derivatives represented by the following general formula (I) are useful as cardiotonics having high cardiotonic activity and low toxicity: STR1 where R1 represents a lower C1 -C4 alkyl group or cyclopropyl