103339-87-3Relevant articles and documents
An efficient method for the synthesis of phenacyl ester-protected dipeptides using neutral alumina-supported sodium carbonate 'Na2CO3/n-Al2O3'
Hashimoto, Chikao,Sugimoto, Kazuhiro,Takahashi, Youhei,Kodomari, Mitsuo
, p. 659 - 662 (2013/09/23)
In the synthesis of dipeptides (Boc-AA1-AA2-OPac: AA1 and AA2 represent amino acids) protected by phenacyl (Pac) ester, amines and solid bases as the base for the conversion of the trifluoroacetic acid (TFA) sal
Design of the Synthetic Route for Peptides and Proteins Based on the Solubility Prediction Method. I. Synthesis and Solubility Properties of Human Proinsulin C-Peptide Fragments
Narita Mitsuaki,Ogura, Toshihiko,Sato, Kazuhiro,Honda, Shinya
, p. 2433 - 2438 (2007/10/02)
The usefulness of the solubility prediction method is demonstrated using relatively small peptide fragments of human proinsulin C-peptide.The propriety of the solubility prediction method for peptides having polar side chains is also examined in the following respects: (1) Peptide intermediates smaller than a heptapeptide have high solubility regardless of their c> values; (2) the c> values of peptide intermediates are useful for judging solubility of peptide intermediates equal to or larger than an octapeptide level; (3) the Pro residue in a central position of a peptide chain is effective for increasing peptide solubility; and (4) there is critical chain length for peptide insolubility caused by a β-sheet aggregation.A strategy suitable for the design of the synthetic route or human proinsulin C-peptide is subsequently discussed on the basis of the solubility prediction of peptide intermediates.
