1033718-06-7

Upstream product

• 218281-35-7 3(S)-tert-butoxycarbonylamino-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 1027014-09-0 Methanesulfonic acid (3R,4S)-4-fluoromethyl-2-oxo-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-yl ester 
• 218281-33-5 3(S)-azide-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 218281-31-3 4(S)-fluoromethyl-3(R)-hydroxy-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 218281-29-9 4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]-2-pyrrolidone 
• 252051-14-2 (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one 
• 190957-22-3 (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one 
• 218281-37-9 3(S)-tert-butoxycarbonylamino-4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]pyrrolidine 
• 1225600-76-9 1-benzyl-4-(fluoromethyl)pyrrolidin-2-one 
• 96449-69-3 1-benzyl-4-(hydroxymethyl)-2-pyrrolidinone 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 

Downstream Products

• 218281-25-5 7-[3(S)-amino-4(S)-fluoromethyl-1-pyrrolidinyl]-6-fluoro-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 218281-25-5 7-[3-(S)-amino-4-(S)-fluoromethyl-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVE

An antibacterial drug having potent antibacterial activities upon various bacteria including resistant strains and high safety is disclosed, which comprises as an active ingredient, quinolone derivatives represented by the following formula (I), its salts

Studies on 8-methoxyquinolones: Synthesis and antibacterial activity of 7-(3-amino-4-substituted)pyrrolidinyl derivatives

A series of 8-methoxyquinolones bearing 3-amino-4-methylpyrrolidines or 3-amino-4-fluoromethylpyrrolidines at the C-7 position was synthesized and their physicochemical and biological properties were evaluated. All of the compounds synthesized showed more

Synthesis and structure-activity relationships of 2-pyridones: II. 8- (fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.