1033719-22-0

Upstream product

• 35391-60-7 ethyl 2-chloro-4-methyl-3-oxopentanoate 
• 1033719-20-8 (4S,5R)-5-(4-chloro-3-fluorophenyl)-4-(6-chloropyridin-3-yl)-4-methylimidazolidine-2-thione 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 1033719-19-5 (1R,2S)-1-(4-Chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propane-1,2-diamine 
• 1199793-07-1 ethyl 2-[(tert-butoxycarbonyl)amino]-2-(6-chloropyridin-3-yl)propanoate 
• 1199793-08-2 tert-butyl [1-(6-chloropyridin-3-yl)-1-methyl-2-oxoethyl] carbamate 
• 1199793-09-3 tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-2-hydroxy-1-methylethyl]carbamate 
• 1199793-10-6 tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-1-methyl-2-oxoethyl]carbamate 
• 1199793-12-8 2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine 
• 1199793-06-0 ethyl 2-amino-2-(6-chloropyridin-3-yl)propanoate 
• 1199793-11-7 2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one 

Downstream Products

• 1033719-23-1 (5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylic acid 
• 1235576-26-7 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane 
• 1235575-91-3 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane 
• 1235576-27-8 (6S)-7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-6-methyl-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane 
• 1235576-07-4 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-methyl-4,7-diazaspiro[2.5]octane 

Relevant academic research and scientific papers

IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROY2.5¨OCTANE RING STRUCTURE

There is provided a novel compound that inhibits the interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits the interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R1 R2, R3, R4, R5, Ar1, and Ar2 in formula (1) each have the same meanings as defined in the specification.

IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE

[Problem to be Solved] There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. [Solution] The present invention provides an imidazothiazole derivative rep