1033723-28-2

Upstream product

• 898538-71-1 4-(benzyloxy)-5-bromo-2-methylbenzaldehyde 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 101093-56-5 4-benzyloxy-2-methyl-benzaldehyde 
• 41438-18-0 4-hydroxy-2-methyl-benzaldehyde 
• 608119-82-0 1-(4-(benzyloxy)-2-methylphenyl)ethanone 
• 100-39-0 benzyl bromide 
• 957774-01-5 4-benzyloxy-5-bromo-2-methylbenzoic acid 
• 875-59-2 4'-hydroxy-2'methylacetophenone 

Downstream Products

• 1033723-60-2 (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-[2-(benzyloxy)-5-(4-ethylbenzyl)-4-methylphenyl]-1-thio-D-glucitol 
• 1033723-38-4 (1S)-1,5-anhydro-1-[5-(4-ethylbenzyl)-2-hydroxy-4-methylphenyl]-1-thio-D-glucitol 
• 1033723-47-5 1-(benzyloxy)-2-bromo-4-(4-ethylbenzyl)-5-methylbenzene 

Relevant academic research and scientific papers

5,5-DIFLUORO- AND 5-FLUORO-5-METHYL-C-GLYCOSIDE DERIVATIVES USEFUL AS DUAL SGLT1 / SGLT2 MODULATORS

The present invention is directed to 5,5-difluoro- and 5-fluoro-5-methyl-C-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.

Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes

The design and synthesis of a novel class of low-absorbable SGLT1 inhibitors are described. To achieve low absorption in the new series, we performed an optimization study based on a strategy to increase TPSA. Fortunately, the optimization of an aglycon m

1-PHENYL 1-THIO-D-GLUCITOL DERIVATIVE

A 1-phenyl 1-thio-D-glucitol compound represented by formula (I) or the like: or a pharmaceutically acceptable salt thereof or a hydrate thereof, or a pharmaceutical preparation comprising the same as an active ingredient is useful as a novel type of prophylactic or therapeutic agent for diabetes, diabetes-related diseases or diabetic complications, which inhibits both SGLT1 and SGLT2 activities to achieve not only suppression of glucose absorption from the digestive tract but also excretion of urinary sugars.