1033723-45-3Relevant articles and documents
Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes
Kuroda, Shoichi,Kobashi, Yohei,Oi, Takahiro,Amada, Hideaki,Okumura-Kitajima, Lisa,Io, Fusayo,Yamamto, Koji,Kakinuma, Hiroyuki
, p. 3534 - 3539 (2018/10/15)
The design and synthesis of a novel class of low-absorbable SGLT1 inhibitors are described. To achieve low absorption in the new series, we performed an optimization study based on a strategy to increase TPSA. Fortunately, the optimization of an aglycon m