1034088-63-5Relevant academic research and scientific papers
An expedient three-component approach to the synthesis of α,α-disubstituted amines under Barbier-like conditions
Sengmany, Stéphane,Le Gall, Erwan,Troupel, Michel
, p. 1031 - 1035 (2008)
A series of α,α-disubstituted amines such as diarylmethylamines, 1,2-diarylethylamines, and amino esters have been prepared in acetonitrile using a simple and expedient three-component Mannich-type procedure involving organic halides, aldehyde derivatives
Three-component synthesis of α-branched amines under barbier-like conditions
Le Gall, Erwan,Haurena, Caroline,Sengmany, Stephane,Martens, Thierry,Troupel, Michel
supporting information; experimental part, p. 7971 - 7973 (2010/02/28)
(Chemical Equation Presented) An array of α-branched amines has been prepared by using an expedient three-component Mannich-type reaction among organic halides, aldehyde derivatives, and amines. The experimental procedure, which is characterized by its simplicity, employs zinc dust for the in situ generation of organozinc reagents. We show that this Barbier-like protocol constitutes a useful entry to diarylmethylamines, 1,2-diarylethylamines, α- or β-amino esters, benzylamines, and β-arylethylamines.
