10342-52-6

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 2389-60-8 Z-Lys(Boc)-OH 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 2212-76-2 N^α-benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt 

Downstream Products

• 47689-13-4 N-(N^α-carbobenzoxy-N^ε-tert-butoxycarbonyl-L-lysyl)glycine 
• 87136-46-7 N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt 
• 87136-45-6 N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Methyl Ester 
• 101250-76-4 Z-Pro-Lys(BOC)-Gly-OH 
• 101249-85-8 N--L-prolyl>-L-lysyl>glycine ditrifluoroacetate 
• 101249-83-6 methyl N-6-<(1,1-dimethylethoxy)carbonyl>-N²-<1-<(phenylmethoxy)carbonyl>-L-prolyl>-L-lysyl>glycinate 
• 211797-31-8 ((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-acetic acid methyl ester 

Relevant academic research and scientific papers

Binding of a hemoregulatory tetrapeptide by a bis-guanidinium crown ether

A synthetic receptor for the molecular recognition of a tetrapeptide in aqueous buffer was obtained by combining a luminescent crown ether with two pyrrole-guanidinium moieties. The compound interacts with ammonium carboxylates of complementary geometry a

Synthesis and evaluation of peptidic maleimides as transglutaminase inhibitors

A series of novel transglutaminase inhibitors was prepared, based on the scaffold of a commonly used peptide substrate and bearing an electrophilic maleimide group. These compounds were evaluated in vitro and shown to lead to irreversible inactivation of tissue transglutaminase. Comparison with inhibitors studied previously provides insight into the steric environment of the enzyme active site.

Synthetic Studies on Sequences of Vitamin K Dependent Proteins. Gla-Arg-Gla Sequences

The synthesis of peptides containing the Gla-Arg-Gla sequence is reported.Nuclear magnetic resonance studies suggest that intramolecular salt bridge interactions occur between the guanidino group of arginine and the γ-carboxyglutamic acid.

Process for producing triglycyl-lysine vasopressin and intermediates therefor

A new process for preparing the cyclic dodecapeptide triglycyl-lysine vasopressin of the formula STR1 which comprises the preparation of a first hexapeptide of formula Boc--Gly--Gly--Gly--Cys(Trt)--Tyr--Phe--NHNH2 and a second hexapeptide of formula H--Gln(Mbh)--Asn(Mbh)--Cys(Trt)--Pro--Lys(Boc)--Gly--NH2 by a series of condensations involving the reaction of an appropriately protected peptide unit having an activated carboxyl with an appropriately protected peptide having a free amino group. Subsequently, the first and second hexapeptides are condensed according to the azide coupling method to obtain the linear protected dodecapeptide of formula Boc--Gly--Gly--Gly--Cys(Trt)--Tyr--Phe--Gln(Mbh)--Asn(Mbh)--Cys(Trt)--Pro--Lys(Boc)--Gly--NH2 ; thereafter the linear protected dodecapeptide is transformed into the desired cyclic dodecapeptide, triglycyllysine vasopressin, by oxidizing and deprotecting processes.