103429-32-9

Basic information

• Product Name: CTAP
• Synonyms: H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2;D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2;CTAP;CYS2, TYR3, ARG5, PEN7-AMIDE;H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(Cys2-Pen7);M.W. 1104.30 C51H69N13O11S2;CTAP-NH2;D-Phe-L-Cys-L-Tyr-D-Trp-L-Arg-L-Thr-L-Pen-L-Thr-NH2
• CAS NO: 103429-32-9
• Molecular Formula: C₅₁H₆₉N₁₃O₁₁S₂
• Molecular Weight: 1104.3
• Product Categories: Peptide;Neuropeptides;Opioid Peptides;Other Opioid Peptides;Other Opioid PeptidesPeptides for Cell Biology;Opioid receptor and opioid-like receptor
• Mol File: 103429-32-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.49 g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: CTAP(CAS DataBase Reference)
• NIST Chemistry Reference: CTAP(103429-32-9)
• EPA Substance Registry System: CTAP(103429-32-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 103429-32-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 103429-32-9 differently. You can refer to the following data:
1. CTAP acts as a selective μ-opioid receptor antagonist with a multitude of applications including the regulation of aggressive behavior in mammals. Activation of μ-opioid receptors in the central nucleus of the amygdala, is responsible for mechanisms related to the control of sodium appetite and regulation of sodium intake.
2. CTAP has been used as a μ-opioid receptor (MOR) antagonist: to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in ratsto determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp+) neurons

Biochem/physiol Actions

CTAP is a peptide antagonist produced from somatostatin analogs.

Upstream product

• 13836-37-8 N^α-Boc-N^G-tosyl-L-arginine 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 863443-56-5 D-Phe-L-Cys-L-Tyr-D-Trp-L-Arg-L-Thr-L-Pen-L-Thr-NH₂ 
• 104323-41-3 N^α-Boc-L-Pen(S-4'-methylbenzyl) 
• 5241-64-5 Boc-D-Trp-OH 
• 13836-37-8 Boc-Arg(Tos)-OH 

Relevant articles and documents

Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays

Topographically constrained analogues of the highly μ-opioid-receptor- selective antagonist CTAP (H-D-Phe-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2, 1) were prepared by solid-phase peptide synthesis. Replacement of the D-Phe residue with conformatio