863443-56-5Relevant academic research and scientific papers
Design and Synthesis of Conformationally Constrained Somatostatin Analogues with High Potency and Specificity for μ Opioid Receptors
Pelton, John T.,Kazmierski, Wieslaw,Gulya, Karoly,Yamamura, Henry I.,Hruby, Victor J.
, p. 2370 - 2375 (1986)
A series of cyclic, conformationally constrained peptides related to somatostatin were designed and synthesized in an effort to develop highly selective and potent peptides for the μ opioid receptor.The following new peptides were prepared and tested for
Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays
Bonner, G. Gregg,Davis, Peg,Stropova, Dagmar,Edsall, Sidney,Yamamura, Henry I.,Porreca, Frank,Hruby, Victor J.
, p. 569 - 580 (2007/10/03)
Topographically constrained analogues of the highly μ-opioid-receptor- selective antagonist CTAP (H-D-Phe-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2, 1) were prepared by solid-phase peptide synthesis. Replacement of the D-Phe residue with conformatio
