103440-55-7

Basic information

• Product Name: Methyl 2-iodo-6-methylbenzoate
• Synonyms: 2-Iodo-6-methyl-benzoic acid methyl ester;2-Iodo-6-methylbenzoic acid methy ester;Methyl 2-iodo-6-methylbenzoate;Benzoic acid, 2-iodo-6-Methyl-, Methyl ester;Methyl 6-iodo-o-toluate, 3-Iodo-2-(methoxycarbonyl)toluene;Methyl2-iodo-6-methylbenzoate97%
• CAS NO: 103440-55-7
• Molecular Formula: C₉H₉IO₂
• Molecular Weight: 276.07
• Product Categories: Pharmaceutical intermediate
• Mol File: 103440-55-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 269.928 °C at 760 mmHg
• Flash Point: 117.048 °C
• Appearance: white crystal powder
• Density: 1.666 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-iodo-6-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-iodo-6-methylbenzoate(103440-55-7)
• EPA Substance Registry System: Methyl 2-iodo-6-methylbenzoate(103440-55-7)

Safety Data

• Hazardous Substances Data: 103440-55-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-iodo-6-methylbenzoate is an organic compound with the chemical formula C9H9IO2. It is a synthetic chemical that contains an iodine atom and a methyl group attached to a benzene ring. Methyl 2-iodo-6-methylbenzoate is often used in the synthesis of various pharmaceutical and agrochemical products. It may also be utilized as a precursor in the production of other organic compounds. Methyl 2-iodo-6-methylbenzoate is known for its potential as a versatile building block in organic chemistry, and it is commonly used in research and industrial applications.

Upstream product

• 67-56-1 methanol 
• 52107-92-3 2-iodo-6-methylbenzoyl chloride 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 54811-50-6 2-iodo-6-methylbenzoic acid 
• 74-88-4 methyl iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 118-90-1 ortho-methylbenzoic acid 

Downstream Products

• 861840-51-9 methyl 2-(bromomethyl)-6-iodobenzoate 
• 866766-96-3 7-iodoisoindolin-1-one 
• 1393901-26-2 tert-butyl 4-(4-((4-((3-oxoisoindolin-4-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate 
• 1393901-28-4 tert-butyl 4-(4-((4-(2-(3-oxoisoindolin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate 
• 1393900-53-2 7-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isoindolin-1-one 
• 179554-11-1 2-allyl-6-methylbenzaldehyde 
• 1402897-13-5 methyl 2-[(E)-2-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)vinyl]-6-methylbenzoate 
• 1365840-82-9 (2-ethenyl-6-methylphenyl)methanol 
• 1261794-19-7 (2-iodo-6-methylphenyl)methanol 

Relevant articles and documents

EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an E3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effectuate ubiquitination, and therefore, degradation (and inhibition) of the target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.