103441-80-1

Basic information

• Product Name: 2-oxo-2-(pyridin-2-yl)ethyl acetate
• CAS NO: 103441-80-1
• Molecular Weight: 179.175
• Mol File: 103441-80-1.mol

Chemical Properties

• CAS DataBase Reference: 2-oxo-2-(pyridin-2-yl)ethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-2-(pyridin-2-yl)ethyl acetate(103441-80-1)
• EPA Substance Registry System: 2-oxo-2-(pyridin-2-yl)ethyl acetate(103441-80-1)

Safety Data

• Hazardous Substances Data: 103441-80-1(Hazardous Substances Data)

Upstream product

• 127-08-2 potassium acetate 
• 17570-98-8 2-(bromoacetyl)pyridine hydrobromide 
• 2457-50-3 2-acetylpyridine N-oxide 
• 108-24-7 acetic anhydride 
• 188897-71-4 N-(1-(pyridin-2-yl)vinyl)acetamide 
• 127-09-3 sodium acetate 
• 115933-92-1 2-(1-acetoxyvinyl)pyridine 1-oxide 
• 1122-62-9 2-acetylpyridine 
• 115933-93-2 2-(1,2-diacetoxyvinyl)pyridine 
• 95836-52-5 2-(α-hydroxyacetyl)pyridine 

Downstream Products

• 95836-52-5 2-(α-hydroxyacetyl)pyridine 

Relevant articles and documents

Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process

Hydrogen peroxide and anhydride mediated transformation of enamides to afford substituted α-acyloxy ketones is described. This transition-metal-free cascade reaction has a broad substrate scope and high efficiency. The acyl intramolecular migration procedure successfully achieved this acyloxylation process under mild conditions and increased the atom efficiency.

Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis

A series of 2-aminothiazoles was synthesized based on a HTS scaffold from a whole-cell screen against Mycobacterium tuberculosis (Mtb). The SAR shows the central thiazole moiety and the 2-pyridyl moiety at C-4 of the thiazole are intolerant to modification. However, the N-2 position of the aminothiazole exhibits high flexibility and we successfully improved the antitubercular activity of the initial hit by more than 128-fold through introduction of substituted benzoyl groups at this position. N-(3-Chlorobenzoyl)-4-(2-pyridinyl) -1,3-thiazol-2-amine (55) emerged as one of the most promising analogues with a MIC of 0.024 μM or 0.008 μg/mL in 7H9 media and therapeutic index of nearly ～300. However, 55 is rapidly metabolized by human liver microsomes (t1/2 = 28 min) with metabolism occurring at the invariant aminothiazole moiety and Mtb develops spontaneous low-level resistance with a frequency of ～10-5.

Hypervalent Iodine Oxidation of Silyl Enol Ethers. A Direct Route to α-Hydroxy Ketones

Hypervalent iodine oxidation of various silyl enol ethers (aromatic, heteroaromatic, and aliphatic) using iodosobenzene-boron trifluoride diethyl ether-water provides a general and direct route for the α-hydroxylation of ketones.The structures of 2-hydroxy- (8) and 3-hydroxy-acetylpyridine (9) are discussed as well as the scope and mechanism of the reaction.

REACTIONS OF 2-ACYLPYRIDINE 1-OXIDES WITH ACID ANHYDRIDES

Treatment of 2-acetyl- and 2-propionyl-pyridine 1-oxides (1a and 1b) with hot acetic, propionic and benzoic anhydrides initially gives the respective enol acylates (A), which further undergo deoxygenative β-acyloxylation to give enediol diacylates (E) and