17570-98-8

Basic information

• Product Name: 2-(BROMOACETYL)PYRIDINE HYDROBROMIDE
• Synonyms: BUTTPARK 32\08-51;2-(BROMOACETYL)PYRIDINE HYDROBROMIDE;2-BROMO-1-PYRIDIN-2-YL-ETHANONE HYDROBROMIDE;2-BROMO-1-(2-PYRIDINYL)-1-ETHANONE HYDROBROMIDE;TIMTEC-BB SBB005581;2-(2-BROMOACETYL)PYRIDINE HYDROBROMIDE;2-(Bromoacetyl)pyridine hydrobromide ,97%;2-Bromo-1-(2-pyridinyl)ethanone hydrobromide
• CAS NO: 17570-98-8
• Molecular Formula: BrH*C₇H₆BrNO
• Molecular Weight: 280.94
• Product Categories: Heterocycle-Pyridine series
• Mol File: 17570-98-8.mol
• Article Data: 26

Chemical Properties

• Melting Point: 205 °C
• Boiling Point: 249.1 °C at 760 mmHg
• Flash Point: 104.5 °C
• Appearance: /
• Density: 1.57g/cm3
• Vapor Pressure: 0.0233mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(BROMOACETYL)PYRIDINE HYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOACETYL)PYRIDINE HYDROBROMIDE(17570-98-8)
• EPA Substance Registry System: 2-(BROMOACETYL)PYRIDINE HYDROBROMIDE(17570-98-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 17570-98-8(Hazardous Substances Data)

Usage

General Description

2-(Bromoacetyl)pyridine hydrobromide is a chemical compound that is widely used in the pharmaceutical and chemical industries. It is a derivative of pyridine and contains a bromoacetyl group, which makes it useful in synthetic organic chemistry. 2-(BROMOACETYL)PYRIDINE HYDROBROMIDE is often used as a reagent for the synthesis of various pharmaceuticals and fine chemicals. It is also used in the production of agrochemicals and other specialty chemicals. Additionally, 2-(Bromoacetyl)pyridine hydrobromide is known for its ability to selectively modify certain functional groups in organic molecules, making it a valuable tool in chemical research and development.

InChI:InChI=1/C7H6BrNO.BrH/c8-5-7(10)6-3-1-2-4-9-6;/h1-4H,5H2;1H

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 113738-31-1 2-acetylpyridinium bromide 
• 1122-62-9 2-acetylpyridine 

Downstream Products

• 103441-80-1 2-oxo-2-(pyridin-2-yl)ethyl acetate 
• 104484-16-4 3-[1-Phenyl-meth-(Z)-ylidene]-6-pyridin-2-yl-[1,4]oxathiin-2-one 
• 139420-56-7 2-Hydrazino-4-(2'-pyridyl)thiazole 
• 115933-97-6 2-pyridacyl benzoate 
• 408498-42-0 2-(pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 
• 950185-64-5 [(2-Nitrophenyl)methyl](4-(2-pyridyl)(1,3-thiazol-2-yl))amine 
• 1001013-86-0 2-(2-(4-iodophenyl)-1-(6-methylpyridin-3-yl)-1H-imidazol-4-yl)pyridine 
• 315702-78-4 N-(3-methylphenyl)-4-(2-pyridinyl)-1,3-thiazol-2-amine 
• 315702-79-5 4-{[4-(2-pyridinyl)-1,3-thiazol-2-yl]amino}phenol 
• 1026661-62-0 (S)-(3,4-difluoro-phenyl)(3-(4-(pyridin-2-yl)-oxazol-2-yl)-piperidin-1-yl)-methanone 
• 1026661-61-9 (S)-(4-fluoro-phenyl)(3-(4-(pyridin-2-yl)-oxazol-2-yl)-piperidin-1-yl)-methanone 
• 845714-00-3 PHA-767491 
• 27302-93-8 2-methanesulfonyl-1-pyridin-2-yl-ethanone 
• 27302-90-5 2-methanesulfinyl-1-pyridin-2-yl-ethanone 

Relevant articles and documents

Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53

We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using a mechanism called zinc metallochaperones (ZMCs) that restore zinc binding by shuttling zinc into cells. We defined biophysical and cellular assays necessary for structure-activity relationship studies using this mechanism. We investigated an alternative class of zinc scaffolds that differ from TSCs by substitution of the thiocarbamoyl moiety with benzothiazolyl, benzoxazolyl, and benzimidazolyl hydrazones. Members of this series bound zinc with similar affinity and functioned to reactivate mutant p53 comparable to the TSCs. Acute toxicity and efficacy assays in rodents demonstrated C1 to be significantly less toxic than the TSCs while demonstrating equivalent growth inhibition. We identified C85 as a ZMC with diminished copper binding that functions as a chemotherapy and radiation sensitizer. We conclude that the benzothiazolyl, benzoxazolyl, and benzimidazolyl hydrazones can function as ZMCs to reactivate mutant p53 in vitro and in vivo.

Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity

In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(L)2(TsO)2]2DMF (1), {[Cd(L)(NO3)2H2O)]DMF}n(2) (where L = 4-(pyridin-4-yl)-2-(2-(pyridin-2- ylm

SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS

Substituted pyrazolo[4,3-b]pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B rece