1034606-50-2

Upstream product

• 1034606-46-6 (R)-tert-butyl 3-((1S,2S)-2-(3,5-difluorobenzyl)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-hydroxy-3-oxopropyl)-3,4-dihydro-isoquinoline-2(1H)-carboxylate 
• 877078-49-4 (S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one 
• 845543-89-7 (R)-tert-butyl3-((4S,5S)-4-(3,5-difluorobenzyl)-2-oxooxazolidin-5-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Downstream Products

• 1034606-52-4 (4S,5S)-4-(3,5-difluorobenzyl)-5-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)oxazolidin-2-one 
• 1034606-41-1 (1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol 
• 1034606-35-3 (S)-2-((R)-3-acetamido-3-isobutyl-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl)-4-phenylbutanamide 
• 1345968-38-8 C₃₂H₃₇F₂N₃O₃ 
• 1034606-39-7 C₃₂H₃₅F₂N₅O₃ 
• 1034606-31-9 C₃₆H₄₃F₂N₃O₃ 
• 1034606-33-1 (S)-2-((S)-3-butyl-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl)propanamide 
• 1345968-31-1 C₄₆H₅₄F₂N₄O₅ 
• 1034607-41-4 C₄₀H₄₃F₂N₅O₄ 
• 1034607-30-1 C₄₄H₅₁F₂N₃O₄ 
• 1034607-32-3 C₃₇H₄₅F₂N₃O₄ 

Relevant academic research and scientific papers

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors

The synthesis, evaluation, and structure-activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal and P-gp deficient mice is compared with data generated in normal rats.

Substituted Tetrahydroisoquinolines as Beta-secretase Inhibitors

There is provided a series of tetrahydroisoquinoline diaminopropane compounds of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R, R8 and R9 are as defined herein, their pharmaceutical compositi