1034607-32-3

Basic information

• Product Name: C₃₇H₄₅F₂N₃O₄
• CAS NO: 1034607-32-3
• Molecular Weight: 633.779
• Mol File: 1034607-32-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₅F₂N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₅F₂N₃O₄(1034607-32-3)
• EPA Substance Registry System: C₃₇H₄₅F₂N₃O₄(1034607-32-3)

Safety Data

• Hazardous Substances Data: 1034607-32-3(Hazardous Substances Data)

Upstream product

• 246144-90-1 (4R,5S)-3-((S)-2-allylhexanoyl)-4-methyl-5-phenyloxazolidin-2-one 
• 353291-30-2 (S)-2-allylhexanoic acid 
• 131636-15-2 (4R,5S)-3-hexanoyl-4-methyl-5-phenyloxazolidin-2-one 
• 142-61-0 Hexanoyl chloride 
• 877078-70-1 (S)-methyl 2-((S)-3-butyl-2-oxopyrrolidin-1-yl)propanoate 
• 877078-69-8 (S)-methyl 2-((S)-2-allylhexanamido)propanoate 
• 104668-15-7 N-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3(S)-carbaldehyde 
• 845543-86-4 (2S,3S)-2-(3,5-difluorobenzyl)-3-((R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-3-hydroxypropanoic acid 
• 1034606-52-4 (4S,5S)-4-(3,5-difluorobenzyl)-5-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)oxazolidin-2-one 
• 1034606-50-2 (4S,5R)-4-(3,5-difluorobenzyl)-5-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)oxazolidin-2-one 
• 1034606-46-6 (R)-tert-butyl 3-((1S,2S)-2-(3,5-difluorobenzyl)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-1-hydroxy-3-oxopropyl)-3,4-dihydro-isoquinoline-2(1H)-carboxylate 
• 877078-49-4 (S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one 
• 1034606-41-1 (1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol 
• 845543-89-7 (R)-tert-butyl3-((4S,5S)-4-(3,5-difluorobenzyl)-2-oxooxazolidin-5-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Downstream Products

• 1034606-33-1 (S)-2-((S)-3-butyl-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl)propanamide 

Relevant articles and documents

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

The synthesis, evaluation, and structure-activity relationships of a class of γ-lactam 1,3-diaminopropan-2-ol transition-state isostere inhibitors of BACE are discussed. Two strategies for optimizing lead compound 1a are presented. Reducing the overall size of the inhibitors resulted in the identification of γ-lactam 1i, whereas the introduction of conformational constraint on the prime-side of the inhibitor generated compounds such as the 3-hydroxypyrrolidine inhibitor 28n. The full in vivo profile of 1i in rats and 28n in Tg 2576 mice is presented.