103476-24-0

Basic information

• Product Name: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT
• Synonyms: 1,4,5-IP3, HEXAPOTASSIUM SALT;IP3;IP3 6K;INS(1,4,5)P3 HEXAPOTASSIUM SALT;INS(1,4,5)P3 6K;INS(1,4,5)IP3 (POTASSIUM SALT);INS(1,4,5)P3;D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE HEXAPOTASSIUM SALT
• CAS NO: 103476-24-0
• Molecular Formula: C₆H₉O₁₅P₃*6K
• Molecular Weight: 648.64
• Product Categories: Inositol Phosphates;Cell Signaling and Neuroscience;Lipids in Cell Signaling;InsP3/Ryanodine receptor
• Mol File: 103476-24-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: H2O: soluble
• CAS DataBase Reference: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT(103476-24-0)
• EPA Substance Registry System: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT(103476-24-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 103476-24-0(Hazardous Substances Data)

Usage

Uses

Used in Cellular Signaling:
D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT is used as a second messenger in cellular signaling for the release of calcium ions from intracellular stores. This process is essential for various cellular functions, including muscle contraction, neurotransmitter release, and gene expression.
Used in Research Applications:
D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT is used as a research tool to study the role of calcium signaling in various biological processes. It helps researchers understand the mechanisms of calcium release and its impact on cellular functions.
Used in Pharmaceutical Industry:
D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT is used as a potential therapeutic agent in the development of drugs targeting calcium signaling pathways. Modulating these pathways can have therapeutic benefits in treating various diseases and conditions.
Used in Biotechnology Industry:
D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE HEXAPOTASSIUM SALT is used in biotechnology applications to manipulate cellular processes and develop novel bioproducts. By understanding and controlling calcium signaling, researchers can engineer cells with specific functions and properties.

Biochem/physiol Actions

Stimulates intracellular calcium mobilization.

InChI:InChI=1/C6H15O15P3.6K/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;;;;/q;6*+1/p-6/t1-,2+,3+,4-,5-,6-;;;;;;/m1....../s1

Upstream product

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• 33021-17-9 (-)-2,3:4,5-di-O-cyclohexylidene-myo-inositol 
• 6763-49-1 (+/-)-1,2:5,6-dicyclohexylidene-myo-inositol 
• 116786-69-7 (+)-3,4-di-O-allyl-5,6-di-O-benzyl-myo-inositol 
• 139978-96-4 (+)-3,4-di-O-allyl-1,2-O-cyclohexylidene-myo-inositol 
• 145789-53-3 (+)-3,4-di-O-allyl-1,2:5,6-di-O-cyclohexylidene-myo-inositol 
• 140148-51-2 (+)-1,3,4-tri-O-allyl-5,6-di-O-benzyl-myo-inositol 
• 101636-71-9 1,6-Di-O-acetyl-2,3:4,5-di-O-cyclohexylidene-D/L-myo-inositol 
• 141611-64-5 1L-1,2,4-tri-O-benzyl-3,5,6-tris-O-(o-xylylenedioxyphosphoryl)-myo-inositol 
• 87-89-8 D-myo-inositol 
• 104873-76-9 2,3,6-tris-O-(phenylmethyl)-D-myo-inositol 
• 6763-47-9 rac-1,2-O-cyclohexylidene-myo-inositol 
• 34361-60-9 1,2:4,5-dicyclohexylidene-myo-inositol 

Relevant articles and documents

An efficient chemoenzymic access to optically active myo-inositol polyphosphates

The 1,4,5-tris-, 1,3,4-tris-, and 1,3,4,5-tetrakis-phosphates of 1D-myo-inositol have been prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. A facile enzymic preparation is also described

Synthesis and Some Properties of D-myo-Inositol 1,4,5-Tris(dihydrogen phosphate)

Optically active myo-inositol 1,4,5-tris(dihydrogen phosphate) 1, which has now been recognized as a second messenger in a new intracellular signal transduction system, has been prepared starting from myo-inositol.The key step, phosphorylation of an adequately protected polyhydroxy derivative, was accomplished by three methods, among which a phosphoramidite method using a new phosphitylating agent, o-xylylene N,N-diethylphosphoramidite, gave the triphosphoric ester in quantitative yield.Optical resolution was effectively realized by derivatization into diastereoisomeric l-menthoxyacetic esters.NMR spectra and optical rotation are shown to depend on the pH of an aqueous solution of compound 1.