1035173-74-0 Usage
Uses
Used in Pharmaceutical Industry:
1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE is used as a reactant in the preparation of sulfonamide analogs of phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474. PI3K inhibitors are a class of drugs that target the PI3K/Akt/mTOR signaling pathway, which plays a crucial role in cell growth, survival, and metabolism. By inhibiting this pathway, these drugs can potentially treat various diseases, including cancer and inflammatory disorders.
In the synthesis of ZSTK474 analogs, 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE serves as a key intermediate, providing a versatile platform for the development of novel PI3K inhibitors with improved potency, selectivity, and pharmacokinetic properties. The use of 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE in the pharmaceutical industry highlights its importance in the discovery and development of new therapeutic agents targeting the PI3K/Akt/mTOR signaling pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 1035173-74-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,1,7 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1035173-74:
(9*1)+(8*0)+(7*3)+(6*5)+(5*1)+(4*7)+(3*3)+(2*7)+(1*4)=120
120 % 10 = 0
So 1035173-74-0 is a valid CAS Registry Number.
1035173-74-0Relevant academic research and scientific papers
ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF
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, (2020/04/25)
A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.
A library of conformationally restricted saturated heterocyclic sulfonyl chlorides
Zhersh, Sergey,Buryanov, Volodymyr V.,Karpenko, Oleksandr V.,Grygorenko, Oleksandr O.,Tolmachev, Andrey A.
, p. 3669 - 3674 (2011/12/16)
An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides
SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS
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Page/Page column 164-165, (2008/12/06)
A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus
