1035404-18-2

Upstream product

• 25563-04-6 o-(p-chlorophenoxy)phenylacetic acid 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 106-48-9 4-chloro-phenol 
• 25958-86-5 2-(4-chlorophenoxy)phenylacetonitrile 

Downstream Products

• 72281-24-4 [2-(8-Chloro-dibenzo[b,f]oxepin-10-ylsulfanyl)-ethyl]-methyl-carbamic acid phenyl ester 
• 1035404-19-3 methyl-N-[2-(4-chloro-2-phenoxyphenyl)-1-oxo-ethyl]-N-methylglycinate 
• 912356-09-3 cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 1383781-81-4 3-[2-(4-chlorophenoxy)phenyl]-4-hydroxy-1-methylpyrrolidine-2-one 

Relevant academic research and scientific papers

Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole

This invention provides improved processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole, asenapine. These processes allow the preparation of asenapine at industrial scale in good yields and high stereoselectivity.

Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors

The p38 MAP kinase is a key enzyme in inflammatory diseases as it is involved in the biosynthesis of proinflammatory cytokines such as TNF-α and IL-1β. Small molecule p38 inhibitors suppress the production of these cytokines and therefore p38 is a promisi

Intermediate compounds for the prepation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole

Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.

Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole

Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.

Tricyclics with analgesic and antidepressant activity: I. [[(Alkylamino)ethyl]thio]dibenzo[b,f]oxepins and 10,11-dihydro derivatives

A series of [[(alkylamino)ethyl]thio]dibenz[b,f]oxepins and their 10,11-dihydro derivatives was synthesized and subjected to broad analgesic/CNS screening. Several analogues of both types, carrying small N-substituents and frequently a nuclear fluorine fu