1035404-19-3

Basic information

• Product Name: ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate
• Synonyms: ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate
• CAS NO: 1035404-19-3
• Molecular Formula: C₁₈H₁₈ClNO₄
• Molecular Weight: 361.8194
• Mol File: 1035404-19-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 474.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• PKA: -1.18±0.70(Predicted)
• CAS DataBase Reference: ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate(1035404-19-3)
• EPA Substance Registry System: ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate(1035404-19-3)

Safety Data

• Hazardous Substances Data: 1035404-19-3(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate is a synthetic chemical compound with the formula C20H21ClNO4. It belongs to the class of N-methylacetamides and contains a phenyl and chlorophenoxy group. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its versatile chemical reactivity. The compound is also being studied for its potential pharmacological properties, including its role as a potential antifungal and antibacterial agent. However, it is important to handle this chemical with caution as it may pose health and environmental risks if not properly managed.

Upstream product

• 5473-12-1 N-methylglycine methylester 
• 1035404-18-2 [2-(4-chloro-phenoxy)-phenyl]-acetyl chloride 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 1366179-34-1 tributylamine salt of 2-(2-(4-chlorophenoxy)phenyl)acetic acid 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 106-48-9 4-chloro-phenol 
• 13515-93-0 N-methylglycine methyl ester hydrochloride 
• 25563-04-6 o-(p-chlorophenoxy)phenylacetic acid 

Downstream Products

• 65576-45-6 asenapine 
• 85650-56-2 trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate 
• 934996-79-9 5-chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino [4,5-c]pyrrole-1-one 
• 912356-09-3 trans 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 912356-09-3 cis 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 1383781-81-4 3-[2-(4-chlorophenoxy)phenyl]-4-hydroxy-1-methylpyrrolidine-2-one 
• 912356-09-3 cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 912356-09-3 trans-11-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 

Relevant articles and documents

A process for the preparation of key intermediate asenapine

The invention provides a chemical synthesis method, in particular to a preparation method of a key intermediate [formula (III)] compound of asenapine capable of serving as a schizophrenia drug. In an anhydrous system, the intermediate [formula (III)] compound is obtained through dehydration of an intermediate [formula (II)] compound and anhydride under the action of a catalyst. The invention further provides a novel method for preparing asenapine by the intermediate [formula (III)]. The provided method has the advantages of simple operation, high yield, environment-friendliness, lower cost, stable technology and the like.

PROCESS FOR THE PREPARATION OF (3ARS,12BRS)-5-CHLORO-2-METHYL-2,3,3A12B-TETRAHYDRO-1HDIBENZO[2,3:6,7] OXEPINO [4,5-C]PYRROLE MALEATE AND IT'S PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to an improved process for the preparation (3aRS,12bRS)-5-Chloro-2-menthyl-2,3,3a,12b-tetrahydro-1Hdibenzo[2,3:6,7]oxepino [4,5-c]pyrrole maleate represented by the compound of formula-1a and its pharmaceutical composition.(F)