10355-53-0Relevant articles and documents
Temperature-controlled sequential Suzuki-Miyaura reactions for preparing unsymmetrical terphenyls
Li, Xinmin,Liu, Chun,Wang, Lei,Ye, Qing,Jin, Xin,Jin, Zilin
, p. 8719 - 8723 (2018)
A one-pot protocol of double Suzuki-Miyaura reactions has been developed for the synthesis of unsymmetrical terphenyls. In the absence of a ligand, potassium bromophenyltrifluoroborate reacts with arylboronic acid and then sequentially with a hetero/aryl bromide by controlling the reaction temperature, providing unsymmetrical p- and m-terphenyl compounds in moderate to good overall yields. This protocol provides a convenient and practical approach to unsymmetrical terphenyls under ligand-free and aerobic conditions.
Nozaki et al.
, p. 1329,1331 (1960)
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Allen,Burness
, p. 175,176 (1949)
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Discovery of Biphenyl-Sulfonamides as Novel β- N-Acetyl- d -Hexosaminidase Inhibitors via Structure-Based Virtual Screening
Chen, Tao,Li, Wen-Qin,Liu, Zheng,Jiang, Wen,Liu, Tian,Yang, Qing,Zhu, Xiao-Lei,Yang, Guang-Fu
, p. 12039 - 12047 (2021/10/20)
Novel insecticidal targets are always in demand due to the development of resistance. OfHex1, a β-N-acetyl-d-hexosaminidase identified in Ostrinia furnacalis (Asian corn borer), is involved in insect chitin catabolism and has proven an ideal target for insecticide development. In this study, structure-based virtual screening, structure simplification, and biological evaluation are used to show that compounds with a biphenyl-sulfonamide skeleton have great potential as OfHex1 inhibitors. Specifically, compounds 10k, 10u, and 10v have Ki values of 4.30, 3.72, and 4.56 μM, respectively, and thus, they are more potent than some reported nonglycosyl-based inhibitors such as phlegmacin B1 (Ki = 26 μM), berberine (Ki = 12 μM), 2 (Ki = 11.2 μM), and 3 (Ki = 28.9 μM). Furthermore, inhibitory kinetic assessments reveal that the target compounds are competitive inhibitors with respect substrate, and based on toxicity predictions, most of them have potent drug properties. The obtained results indicate that the biphenyl-sulfonamide skeleton characterized by simple chemical structure, synthetic tractability, potent activity, and low toxicity has potential for further development in pest management targeting OfHex1.
Carbon-coated magnetic palladium: Applications in partial oxidation of alcohols and coupling reactions
Baig, R.B. Nasir,Nadagouda, Mallikarjuna N.,Varma, Rajender S.
supporting information, p. 4333 - 4338 (2014/09/29)
A carbon-coated magnetic Pd catalyst has been synthesized via in situ generation of nanoferrites and incorporation of carbon from renewable cellulose via calcination; the catalyst can be used for oxidation of alcohols, amination reaction and arylation of aryl halides (cross-coupling reaction). the Partner Organisations 2014.