1035571-28-8

Basic information

• Product Name: 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone
• Synonyms: 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone
• CAS NO: 1035571-28-8
• Molecular Weight: 342.179
• Mol File: 1035571-28-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone(1035571-28-8)
• EPA Substance Registry System: 2-(3,5-dichloropyridin-4-yl)-1-(2,4-dimethoxy-3-hydroxyphenyl)ethanone(1035571-28-8)

Safety Data

• Hazardous Substances Data: 1035571-28-8(Hazardous Substances Data)

Upstream product

• 208043-54-3 [2-(3,5-Dichloro-pyridin-4-yl)-1-oxoethyl]-2,3,4-trimethoxybenzene 
• 100868-46-0 3,5-dichloro-4-picoline 
• 6395-18-2 methyl 2,3,4-trimethoxybenzoate 
• 208043-53-2 [2-(3,5-Dichloro-pyridin-4-yl)-1-oxoethyl]-2,3-dihydroxy-4-methoxybenzene 
• 74-88-4 methyl iodide 

Downstream Products

• 1035571-47-1 {6-[2-(3,5-dichloropyridin-4-yl)-acetyl]-2,3-dimethoxyphenoxy}acetic acid ethyl ester 
• 1035572-17-8 1-(3-ethoxy-2,4-dimethoxyphenyl)-2-(3,5-dichloro-pyridin-4-yl)ethanone 
• 1035572-18-9 1-(3-cyclopropylmethoxy-2,4-dimethoxyphenyl)-2-(3,5-dichloropyridin-4-yl)ethanone 

Relevant articles and documents

Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4- pyridyl)acetyl]-2,3-dimethoxyphenoxy}- N -propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis

Development of orally available phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory drugs has been going on for decades. However, only roflumilast has received FDA approval. One key challenge has been the low therapeutic window observed in the clin