103566-04-7

Upstream product

• 115164-07-3 9-(p-chlorophenyl)hypoxanthine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 87-42-3 6-chloropurine 
• 93270-68-9 5-amino-1-(p-chlorophenyl)imidazole-4-carboxamide 
• 926662-87-5 ethyl 5‐amino‐1‐(4‐chlorophenyl)‐1H‐imidazole‐4‐carboxylate 
• 106-47-8 4-chloro-aniline 
• 103505-49-3 6-chloro-N₄-(4-chlorophenyl)-4,5-pyrimidinediamine 
• 3724-43-4 Vilsmeier reagent 

Downstream Products

• 429675-79-6 3-(5-amino-1-(p-chlorophenyl)imidazol-4-yl)-1,2,4-triazole 
• 429675-77-4 7-(p-chlorophenyl)-1,2,4-triazolo[3,4-i]purine 
• 429675-78-5 7-(p-chlorophenyl)-1,2,4-triazolo[5,1-i]purine 
• 429675-76-3 9-(p-chlorophenyl)-6-hydrazinopurine 

Relevant academic research and scientific papers

Regioselective N-9 arylation of purines employing arylboronic acids in the presence of Cu(II)

9-Arylpurines are efficiently formed with complete regioselectivity when purines are treated with arylboronic acids in the presence of copper(II) acetate. A variety of substituents on both coupling partners are well tolerated.

METHOD FOR SYNTHESIZING DIVERSELY SUBSTITUTED PURINES

The present invention relates to a method for synthesizing diversely substituted purines starting from a pyrimidine. Formula (I). The method comprises the formation of an amidine group on the pyrimidine by implementing a Vilsmeier type reagent, the functi

A One-Pot Synthesis of Highly Functionalized Purines

Highly substituted purines were synthesized in good to high yields through a one-pot straightforward metal-free scalable method, using the Traube synthesis adapted to Vilsmeier-type reagents. From 5-amino-4-chloropyrimidines, new 9-aryl-substituted chloropurines and intermediates for peptide nucleic acid synthesis were prepared. Variant procedures allowing a rapid synthesis of ribonucleosides and 7-benzylpurine from 5-amidino-6-aminopyrimidines are also reported to illustrate the high potential of this versatile toolbox. This route appears to be particularly interesting in the field of nucleic acids for a direct and rapid access to various new 8-alkylpurine nucleosides.

ETHYL CHLOROFORMATE/DMF IN ORGANIC SYNTHESIS. I. A NOVEL REAGENT FOR RING CLOSURE OF 5-AMINO-1-ARYL-4-IMIDAZOLECARBOXAMIDES TO THEIR HYPOXANTHINE DERIVATIVES

Ethyl chloroformate/dimethylformamide mixture is used as a new reagent for adding a carbon (C-2 in the purine nucleus) at the formic acid oxidation level during ring closure of 5-amino-1-aryl-4-imidazolecarboxamides leading to the formation of the corresp