103606-72-0

Basic information

• Product Name: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE
• Synonyms: AKOS PRN-0006;METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE;Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate;ethyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate;Methyl 2-(3-hydroxyprop-1-yn-1-yl)
• CAS NO: 103606-72-0
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• Mol File: 103606-72-0.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 337 °C at 760 mmHg
• Flash Point: 146.9 °C
• Appearance: /
• Density: 1.21 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE(103606-72-0)
• EPA Substance Registry System: METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE(103606-72-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 103606-72-0(Hazardous Substances Data)

Usage

General Description

"METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE" is a chemical compound with the molecular formula C11H10O3. It is also known by the alternative name, 2-(3-hydroxyprop-1-ynyl)benzoic acid methyl ester. METHYL 2-(3-HYDROXYPROP-1-YNYL)BENZOATE is a derivative of benzoic acid and contains a hydroxy group and a propynyl group at different positions on the benzene ring. It is commonly used in organic synthesis and chemical research due to its unique chemical structure and properties, and it may have potential applications in pharmaceuticals or other industrial uses.

Upstream product

• 74-86-2 acetylene 
• 88-67-5 2-Iodobenzoic acid 
• 119-36-8 methyl salicylate 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 107-19-7 propargyl alcohol 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 610-97-9 o-iodo-methyl-benzoic acid 

Downstream Products

• 214260-70-5 methyl 2-(3-bromoprop-1-yn-1-yl)benzoate 
• 133446-35-2 methyl 2-(3-methoxy-1-propynyl)benzoate 
• 1188540-92-2 2-{3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl}benzoic acid methyl ester 
• 81329-74-0 3-(2-(methoxycarbonyl)phenyl)propanoic acid 
• 1421710-50-0 methyl 2-(3-iodoprop-1-ynyl)benzoate 
• 1392119-13-9 tert-butoxy-[4-(2,3-difluorophenyl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]acetic acid methyl ester 
• 1392119-12-8 [4-(2,3-difluorophenyl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]hydroxyacetic acid methyl ester 
• 1392119-11-7 2-[4-(2,3-difluorophenyl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-y]-2-[trimethylsilanyloxy]acetonitrile 
• 1392119-10-6 4-(2,3-difluorophenyl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-3-carbaldehyde 

Relevant articles and documents

Synthesis of biaryls using nickel-catalyzed [2+2+2] cocyclization

Methods of synthesizing biaryls using nickel-catalyzed [2+2+2] cocyclization were developed. Two ways for the synthesis of biaryl using [2+2+2] cocyclization were investigated: one method is that biaryls synthesized from alkyne having a phenyl group and 2

Enantioselective Lactonization by π-Acid-Catalyzed Allylic Substitution: A Complement to π-Allylmetal Chemistry

Asymmetric allylic alkylation (AAA) is a powerful method for the formation of highly useful, non-racemic allylic compounds. Here we present a complementary enantioselective process that generates allylic lactones via π-acid catalysis. More specifically, a

Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters

4-Chloroisocoumarins can be conveniently prepared from 2-alkynylaryloate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chlorosuccinimide (NCS) in the presence of 10 mol % trimethylsilyl chloride (TMSCl), which leads to 6-endo-dig-selective chlorinative annulation to give the desired products in moderate to quantitative yields. The procedure employs readily available reagents and can be conveniently carried out on a wide scope of substrates under mild conditions (0 °C to rt). Furthermore, the reaction is scalable for gram-scale preparation of 4-chloroisocoumarins. Additionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iodosuccinimide (NIS), respectively.