81329-74-0

Usage

Explanation

This is the scientific name of the chemical compound, also known as fenofibric acid.

Explanation

The primary use of 2-(methoxycarbonyl)benzenepropanoic acid is to help manage lipid disorders by reducing high levels of cholesterol and triglycerides in the body.

Explanation

Fenofibric acid belongs to the class of fibrates, which are medications that help lower triglyceride production and increase "good" cholesterol levels.

Explanation

Fenofibric acid is an active metabolite of fenofibrate, a commonly used medication for controlling lipid levels.

Explanation

Fenofibric acid is believed to work by activating the PPAR-alpha receptor, which plays a role in regulating lipid metabolism in the body.

Explanation

Fenofibric acid is considered a potent and effective medication for managing lipid disorders, helping to reduce the risk of cardiovascular disease.

Purpose

Treatment of high cholesterol and triglyceride levels

Classification

Fibrate

Active Metabolite

Fenofibrate

Mechanism of Action

Activation of PPAR-alpha receptor

Effectiveness

Potent and effective

Upstream product

• 67-56-1 methanol 
• 5714-98-7 3-(2-carboxyphenyl)propionic acid anhydride 
• 7171-60-0 2-methoxymethylene-1-tetralone 
• 4122-56-9 methyl o-formylbenzoate 
• 612-40-8 2-carboxycinnamic acid 
• 25040-17-9 methyl 3-[2-(methoxycarbonyl)phenyl]propionate 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 135-19-3 β-naphthol 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 103606-72-0 methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate 
• 106515-76-8 2-(3-Hydroxypropyl)benzoesaeure-methylester 
• 119-67-5 o-carboxybenzaldehyde 
• 98116-20-2 (E)-3-(2-Methoxycarbonylphenyl)propenoic acid 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 106515-77-9 methyl 2-(3-oxopropane)benzoate 
• 1370650-94-4 4-bromo-1-oxo-N-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide 
• 1370650-73-9 methyl 2-(3-chloro-3-oxopropyl)benzoate 
• 1370650-78-4 methyl 2-(3-azido-3-oxopropyl)benzoate 
• 1370650-84-2 methyl 2-(2-isocyanatoethyl)benzoate 
• 1370650-88-6 methyl 2-(2-(3-phenylureido)ethyl)benzoate 
• 13797-31-4 1-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid phenylamide 
• 491-30-5 1-isoquinolone 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 32202-61-2 4-aminoindan 

Relevant academic research and scientific papers

New preparation method of 4-aminoindan compound

The invention relates to a new preparation method of a 4-aminoindan compound. 4-Aminoindan is an important medical intermediate. With carboxybenzaldehyde as an initial raw material, through esterification, condensation, cyclization, reduction elimination, Curtius rearrangement, an amidogen deprotection reaction and a hydrogenation reaction in sequence, the 4-aminoindan is prepared. According to the method, the problems of difficult generation of isomers, difficult separation of substitution products and the like in a traditional method are solved, the whole preparation method is convenient toimplement, the yield is high, and the method has great industrial prospects.

A General Way to Construct Arene-Fused Seven-Membered Nitrogen Heterocycles

Imines react with seven-membered cyclic anhydrides (prepared from the corresponding dicarboxylic acids by a recently discovered in-situ cyclodehydration protocol) by the Castagnoli–Cushman reaction pathway to give privileged seven-membered arene-fused nitrogen-heterocyclic compounds with reagent-controlled diversity of the skeleton and peripheral groups.

γ-Lactone Synthesis via Palladium(II)-Catalyzed Lactonization of Unactivated Methylene C(sp3)-H Bonds

A palladium(II)-catalyzed intramolecular lactonization of unactivated methylene C(sp3)-H bonds using PIP bidentate auxiliary is described. This method provides an efficient and concise pathway to synthesize functionalized γ-lactones.

New synthetic methodology for construction of the 3,4-dihydroisoquinolinone skeleton: A key structure for isoquinoline alkaloids

We hereby report a new method for preparation of 3,4-dihydroisoquinolin- 1(2H)-one as well as isoquinolin-1(2H)-one skeleton starting from the methyl 2-(3-methoxy-3-oxopropyl)benzoate. The ester functionality, adjacent to the methylene, was regiospecifically converted to the desired acyl azide. The isocyanate was transformed into the monoisocyanate by Curtius rearrangement followed by trapping with aniline. The formed urea derivative was cyclized with NaH to give a 3,4-dihydroisoquinolin-1(2H)-one derivative. Incorporation of a double bond into the six-membered ring followed by removal of the substituent resulted in the formation of isoquinolin-1(2H)-one skeleton.

Ozonolysis of enol ethers. Part 10. Ozonization of enol ethers from 1,2- and 1,3-dicarbonyl compounds: Direct quantitative synthesis of phthalonic acid anhydride

The results of ozonolyses of enol ethers from 1.2- and 1.3-dicarbonyl compounds presented here strongly indicate that these reactions do not proceed via the established Criegee ozonolysis mechanism for nucleophilic C=C bonds. The quantitative one-step synthesis of phthalonic acid anhydride via ozonolysis of 2-(methoxymethyliden)-1H-inden-1.3(2H)-dione (28a) is described. Furthermore, a revision of the theory of alkene ozonolysis in the presence of tetracyanoethylene (TCNE) is proposed on the basis of a single-electron-transfer (SET) chemistry.

Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitors: 2-oxetanones with a side chain mimicking the folded structure of 1233A.

To mimic the folded side chain conformation of 1233A (1), which is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitor, 1233A analogs with aromatic rings in the side chain were synthesized. The 2-oxetanone moiety was kept intact. Among 1233A and its synthetic analogs, trans-3-hydroxymethyl-4-[2-(7-methoxycarbonyl-1-naphthyl)ethyl]-2-oxe tanone (23) showed the highest HMG-CoA synthase inhibitory activity in vitro. The structure-activity relationship at the side chain is discussed.