1036204-61-1

Basic information

• Product Name: Propargyl-PEG13-alcohol
• Synonyms: Propargyl-PEG13-alcohol;Propargyl-PEG12-alcohol;Propargyl-PEG12-OH
• CAS NO: 1036204-61-1
• Molecular Formula: C27H52O13
• Molecular Weight: 584.69398
• Mol File: 1036204-61-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 613.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.099±0.06 g/cm3(Predicted)
• Solubility: Soluble in Water, DMSO, DMF, DCM
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: Propargyl-PEG13-alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl-PEG13-alcohol(1036204-61-1)
• EPA Substance Registry System: Propargyl-PEG13-alcohol(1036204-61-1)

Safety Data

• Hazardous Substances Data: 1036204-61-1(Hazardous Substances Data)

Usage

Description

Propargyl-PEG13-alcohol is a hydrophilic molecule that can react with azide-bearing compounds or biomolecules via copper-catalyzed Click Chemistry to form stable triazole linkages. Its hydrophilic PEG units increase the water-solubility of the molecule, making it suitable for various applications.

Uses

Used in Bioconjugation:
Propargyl-PEG13-alcohol is used as a reactant in the synthesis of fluorescent probes targeting β-amyloid plaques. The hydrophilic PEG units enhance the water-solubility of the molecule, allowing for efficient conjugation with azide-bearing compounds or biomolecules via copper-catalyzed Click Chemistry.
Used in Drug Delivery Systems:
Propargyl-PEG13-alcohol can be used as a component in drug delivery systems, where its hydrophilic nature and ability to form stable triazole linkages can improve the solubility and targeting of therapeutic agents.
Used in Diagnostic Imaging:
The hydrophilic PEG units and stable triazole linkages formed by Propargyl-PEG13-alcohol can be utilized in the development of diagnostic imaging agents, enhancing the contrast and specificity of imaging techniques.
Used in Biosensors:
Propargyl-PEG13-alcohol can be employed in the design of biosensors, where its hydrophilic nature and stable triazole linkages can improve the sensitivity and selectivity of the sensor.
Used in Tissue Engineering:
The hydrophilic PEG units and stable triazole linkages formed by Propargyl-PEG13-alcohol can be utilized in tissue engineering applications, where they can improve the biocompatibility and stability of engineered tissues.

Upstream product

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Relevant articles and documents

Design, Synthesis, and Self-Assembly Studies of a Suite of Monodisperse, Facially Amphiphilic, Protein–Dendron Conjugates

The custom design of protein–dendron amphiphilic macromolecules is at the forefront of macromolecular engineering. Macromolecules with this architecture are very interesting because of their ability to self-assemble into various biomimetic nanoscopic structures. However, to date, there are no reports on this concept due to technical challenges associated with the chemical synthesis. Towards that end, herein, a new chemical methodology for the modular synthesis of a suite of monodisperse, facially amphiphilic, protein–dendron bioconjugates is reported. Benzyl ether dendrons of different generations (G1–G4) are coupled to monodisperse cetyl ethylene glycol to form macromolecular amphiphilic activity-based probes (AABPs) with a single protein reactive functionality. Micelle-assisted protein labeling technology is utilized for site-specific conjugation of macromolecular AABPs to globular proteins to make monodisperse, facially amphiphilic, protein–dendron bioconjugates. These biohybrid conjugates have the ability to self-assemble into supramolecular protein nanoassemblies. Self-assembly is primarily mediated by strong hydrophobic interactions of the benzyl ether dendron domain. The size, surface charge, and oligomeric state of protein nanoassemblies could be systematically tuned by choosing an appropriate dendron or protein of interest. This chemical method discloses a new way to custom-make monodisperse, facially amphiphilic, protein–dendron bioconjugates.

HYDROPHOBIN MIMICS: PROCESS FOR PREPARATION THEREOF

The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.