1036278-66-6Relevant articles and documents
The first enantioselective synthesis of palinurin
Perez, Manuel,Perez, Daniel I.,Martinez, Ana,Castro, Ana,Gomez, Generosa,Fall, Yagamare
supporting information; experimental part, p. 3252 - 3254 (2009/12/01)
The first enantioselective synthesis of palinurin has been accomplished starting from commercially available furaldehyde and (R)-methyl-3-hydroxy-2- methylpropionate; the key steps of the synthesis include the use of a chiral pyrrolidine to create the chiral tetronic moiety, and Horner-Wadsworth-Emmons, Wittig and Wittig-Horner reactions to construct the alkene units.
Furan derivatives, method of synthesis and uses thereof
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Page/Page column 31, (2008/12/06)
The present invention relates to furan derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.