103648-08-4

Basic information

• Product Name: 1-Propanone, 1-(1-hydroxycyclohexyl)-2,2-dimethyl-
• CAS NO: 103648-08-4
• Molecular Formula: C11H20O2
• Molecular Weight: 184.279
• Mol File: 103648-08-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(1-hydroxycyclohexyl)-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(1-hydroxycyclohexyl)-2,2-dimethyl-(103648-08-4)
• EPA Substance Registry System: 1-Propanone, 1-(1-hydroxycyclohexyl)-2,2-dimethyl-(103648-08-4)

Safety Data

• Hazardous Substances Data: 103648-08-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Sweet, floral

Uses

Fragrance ingredient in cosmetics, personal care products, and household cleaners; flavoring agent in food and beverages; solvent in the manufacturing of fragrances; plasticizer in polymer formulations

Toxicity

Low acute toxicity, but prolonged exposure may cause irritation to skin, eyes, and respiratory system

Handling precautions

Handle with care and in a well-ventilated area.

Upstream product

• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 
• 57182-15-7 1-chloro-2,2-dimethyl-1-(2,6-dimethylphenylimino)propane 
• 39627-97-9 2,2-dimethyl-N-(2,6-dimethylphenyl)propionamide 
• 594-19-4 tert.-butyl lithium 
• 108-94-1 cyclohexanone 
• 200886-76-6 1-{1-[(Z)-2,6-Dimethyl-phenylimino]-2,2-dimethyl-propyl}-cyclohexanol 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

HIGH YIELD ACYL ANION TRANSFER REACTIONS: NUCLEOPHILIC ACYLATION OF ALDEHYDES

Aldehydes be may acylated to give R'CH(OH)C(O)R in good yield by the RLi/CO in situ procedure at very low temperatures.Examples are given of ketone acylations which demonstrate the advantages of 1:1 RLi/substrate stoichiometry and the use of lower (-135 deg C) temperature.

Imidoyllithiums: Masked acyllithium reagents

The reaction of chloroimines 1 with an excess of lithium powder and a catalytic amount of naphthalene (4 mol %) in THF at -78°C leads to the corresponding imidoyllithium intermediates 2, which by treatment with different electrophiles [PriCHO, Bu(t)CHO, n-C5H11CHO, PhCHO, Et2CO, (CH2)5CO, EtOCOCl, MeOCSCl, n-C7H15CON(Me)OMe] at -78 to 20°C and final hydrolysis with water affords functionalysed imines 3. For starting material la is necessary to filter off the excess of lithium at the end of the lithiation step in order to get compounds 3, without filtration amines 4 are the reaction products isolated. Hydrolysis of compounds 3 either during chromatographic purification or by acidic hydrolysis (2 N HCl, THF) gives the expected functionalised ketones 5.