
Tetrahedron Letters p. 4907 - 4910 (1983)
Update date:2022-08-10
Topics:
Seyferth, Dietmar
Weinstein, Robert M.
Wang, Wei-Liang
Hui, Richard C.
Aldehydes be may acylated to give R'CH(OH)C(O)R in good yield by the RLi/CO in situ procedure at very low temperatures.Examples are given of ketone acylations which demonstrate the advantages of 1:1 RLi/substrate stoichiometry and the use of lower (-135 deg C) temperature.
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