103649-07-6

Upstream product

• 56164-66-0 1-propyl-cyclohexanecarboxylic acid 
• 2043-61-0 cyclohexanecarbaldehyde 
• 100-50-5 3-Cyclohexene-1-carboxaldehyde 
• 107-08-4 1-iodo-propane 
• 49707-50-8 N-t-butylpentylideneamine 
• 110-62-3 pentanal 
• 98-89-5 Cyclohexanecarboxylic acid 
• 85003-56-1 (1-Propyl-cyclohexyl)-methanol 
• 10420-49-2 1-allyl-3-cyclohexene-1-carboxaldehyde 
• 29517-58-6 1-allylcyclohexanecarbaldehyde 

Downstream Products

• 1462-27-7 butanoyl cyclohexane 
• 433219-72-8 (Z)-7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-4-(tert-butyl-dimethyl-silanyloxy)-4-(1-propyl-cyclohexyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester 
• 212310-11-7 (Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-propyl-cyclohexyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester 
• 433219-66-0 (E)-1-iodo-4-(tert-butyldimethylsiloxy)-5,5-pentamethylene-1-octene 
• 433219-65-9 tert-butyl-dimethyl-[1-(1-propyl-cyclohexyl)-but-3-ynyloxy]-silane 

Relevant academic research and scientific papers

α,α-Cyclobisalkylation of aldehydes via ω-haloaldimines

The construction of a cycloalkyl ring at the α-position of aldehydes by cyclization of ω-haloaldimines is described. Alkylation of the corresponding aldimines with α,ω-dihaloalkanes followed by treatment with LDA results in a convenient access to α,α-cycl

Radical Carbonyl Propargylation by Dual Catalysis

Carbonyl propargylation has been established as a valuable tool in the realm of carbon–carbon bond forming reactions. The 1,3-enyne moiety has been recognized as an alternative pronucleophile in the above transformation through an ionic mechanism. Herein, we report for the first time, the radical carbonyl propargylation through dual chromium/photoredox catalysis. A library of valuable homopropargylic alcohols bearing all-carbon quaternary centers could be obtained by a catalytic radical three-component coupling of 1,3-enynes, aldehydes and suitable radical precursors (41 examples). This redox-neutral multi-component reaction occurs under very mild conditions and shows high functional group tolerance. Remarkably, bench-stable, non-toxic, and inexpensive CrCl3 could be employed as a chromium source. Preliminary mechanistic investigations suggest a radical-polar crossover mechanism, which offers a complementary and novel approach towards the preparation of valuable synthetic architectures from simple chemicals.

Development of a highly selective EP2-receptor agonist. Part 1: Identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of α and ω-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an ω-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. Copyright