1036750-83-0

Basic information

• Product Name: 3-AMINO-6-BROMOBIPHENYL
• Synonyms: 3-AMINO-6-BROMOBIPHENYL;4-BROMO-3-PHENYLANILINE;6-BROMOBIPHENYL-3-AMINE;6-BroMo-[1,1'-biphenyl]-3-aMine;6-Bromo-biphenyl-3-ylamine
• CAS NO: 1036750-83-0
• Molecular Formula: C₁₂H₁₀BrN
• Molecular Weight: 248
• Mol File: 1036750-83-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-AMINO-6-BROMOBIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-6-BROMOBIPHENYL(1036750-83-0)
• EPA Substance Registry System: 3-AMINO-6-BROMOBIPHENYL(1036750-83-0)

Safety Data

• Hazardous Substances Data: 1036750-83-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-6-BROMOBIPHENYL is used as a reactant for the preparation of chloro aryl indolecarboxamide derivatives, which serve as inhibitors of human liver glycogen phosphorylase a. These derivatives have potential applications in the development of drugs targeting metabolic disorders and related health issues.
Used in Material Science:
3-AMINO-6-BROMOBIPHENYL is utilized in the synthesis of large and stable colloidal graphene quantum dots with tunable size. These quantum dots have significant potential in various fields, including optoelectronics, energy storage, and sensing applications, due to their unique electronic and optical properties.

Upstream product

• 489409-86-1 2-bromo-5-nitro-1,1'-biphenyl 
• 63037-64-9 4-bromo-3-iodoaniline 
• 98-80-6 phenylboronic acid 
• 29608-75-1 2-amino-5-nitro-biphenyl 
• 13296-94-1 2-bromo-4-nitroaniline 

Downstream Products

• 620596-66-9 N-(6-bromobiphenyl-3-yl)-5-chloro-1H-indole-2-carboxamide 
• 1428635-34-0 C₅₂H₃₄N₄ 
• 1428635-33-9 C₄₈H₃₀N₂O 
• 1428635-17-9 C₃₆H₂₄N₂ 
• 1428635-15-7 C₃₆H₂₅ClN₂ 
• 1428635-14-6 C₃₀H₂₂N₂ 

Relevant articles and documents

Intramolecular Remote C-H Activation via Sequential 1,4-Palladium Migration to Access Fused Polycycles

An unprecedented intramolecular remote C-H activation via sequential 1,4-palladium migration with an aromatic ring as a conveyor has been described. This reaction provides an efficient route to construct diverse polycyclic frameworks in moderate to good yield via palladium-catalyzed remote C-H activation/alkene insertion, arylation, alkenylation, and the Heck reaction. The preliminary mechanistic studies revealed that the 1,4-palladium migration process was reversible.

Synthesis of large, stable colloidal graphene quantum dots with tunable size

We report a solution-chemistry-based approach to large, stable colloidal graphene quantum dots with uniform size and shape. The versatility of solution chemistry allows us to tune the structures of the graphenes and thus their properties.

Structurally simple inhibitors of lanosterol 14α-demethylase are efficacious in a rodent model of acute Chagas disease

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display potency for killing T. cruzi amastigotes in vitro with values of EC 50 in the 0.4-10 nM range. Two compounds were selected for efficacy studies in a mouse model of acute Chagas disease. At oral doses of 20-50 mg/kg given after establishment of parasite infection, the compounds reduced parasitemia in the blood to undetectable levels, and analysis of remaining parasites by PCR revealed a lack of parasites in the majority of animals. These dialkyl imidazoles are substantially less expensive to produce than posaconazole and are appropriate for further development toward an anti-Chagas disease clinical candidate.