1036844-35-5Relevant academic research and scientific papers
Self-cleavable chemiluminescent probes suitable for protease sensing
Richard, Jean-Alexandre,Jean, Ludovic,Schenkels, Caroline,Massonneau, Marc,Romieu, Anthony,Renard, Pierre-Yves
scheme or table, p. 2941 - 2957 (2011/02/26)
A new generation of dioxetane-based chemiluminescent substrates suitable for detecting protease activities is described. Our strategy involves the use of a self-cleavable spacer as the key molecular component of these protease-sensitive chemiluminescent p
7-Hydroxycoumarin-hemicyanine hybrids: A new class of far-red emitting fluorogenic dyes
Richard, Jean-Alexandre,Massonneau, Marc,Renard, Pierre-Yves,Romieu, Anthony
supporting information; experimental part, p. 4175 - 4178 (2009/06/06)
(Chemical Equation Presented) The design and synthesis of novel water-soluble far-red emitting phenol-based fluorophores derived from 7-hydroxycoumarin are described. These hemicyanine-coumarin hybrids display promising spectroscopic features such as large apparent Stokes shift (ranging from 60 to 140 nm) and fluorescence emission maxima between 620 and 720 nm in physiological conditions. Their utility was then illustrated by the preparation of an original fluorogenic probe of penicillin G acylase (PGA) whose fluorescence is unveiled through an enzyme-initiated domino reaction.
