1036959-23-5

Basic information

• Product Name: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)
• Synonyms: Vildagliptin IMpurity 2 (Mixture of DiastereoMers);Vildagliptin IMpurity 2;Vildagliptin IMPURITY B;(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile;Vildagliptin Impurity 1;(2S)-1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile;(2S,2'S)-1,1'-(2,2'-((3-hydroxyadamantan-1-yl)azanediyl)bis(acetyl))bis(pyrrolidine-2-carbonitrile)
• CAS NO: 1036959-23-5
• Molecular Formula: C₂₄H₃₃N₅O₃
• Molecular Weight: 439.55052
• Mol File: 1036959-23-5.mol

Chemical Properties

• Boiling Point: 730.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 14.99±0.40(Predicted)
• CAS DataBase Reference: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)(CAS DataBase Reference)
• NIST Chemistry Reference: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)(1036959-23-5)
• EPA Substance Registry System: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)(1036959-23-5)

Safety Data

• Hazardous Substances Data: 1036959-23-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Vildagliptin IMpurity 2 (Mixture of DiastereoMers) is used as a reference material for the development and quality control of Vildagliptin-containing medications. It helps ensure the purity and efficacy of the active pharmaceutical ingredient (API) by providing a benchmark for comparison during the manufacturing process.
Used in Research and Development:
In the field of pharmaceutical research and development, Vildagliptin IMpurity 2 (Mixture of DiastereoMers) serves as a valuable tool for studying the effects of impurities on the overall performance and safety of Vildagliptin. This can lead to the optimization of the drug's formulation and the development of more effective treatments for diabetes.

Upstream product

• 23500-10-9 (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid 
• 147-85-3 L-proline 
• 702-82-9 3-aminoadamantan-1-ol 
• 207557-35-5 (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 

Relevant articles and documents

2 - substituted pyrrolidines compound, preparation method and its application in the preparation of the peculiar smell (by machine translation)

The invention discloses a 2 - substituted pyrrolidines compound, preparation method and its application in the preparation of the peculiar smell, the tetrahydro-pyrrole derivatives of formula (I) has the structure as illustrated, using the intermediate synthesis when the peculiar smell, the preparation method of the original source of auxiliary materials are cheap and easily obtained, the process route is short, low cost, mild conditions in the reaction process of the security, without the special requirements of the device, can be suitable for industrial production. (by machine translation)

PROCESS FOR PREPARING VILDAGLIPTIN

The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2′S)-1,1′-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and compositions comprising a compound for formula (II). Furthermore, the invention relates to processes for determining the purity of vildagliptin using a compound of formula (II).