1037047-31-6Relevant articles and documents
Synthesis of 2,3-disubstituted indoles from alkynylanilines and 2-chlorophenols using palladium–dihydroxyterphenylphosphine catalyst
Yamaguchi, Miyuki,Ogihara, Kota,Konishi, Hideyuki,Manabe, Kei
, (2020/04/15)
2,3-Disubstituted indoles bearing 2-hydroxyphenyl moieties at their C3 positions were synthesized from readily available 2-chlorophenols and alkynylanilines via aminopalladation/reductive elimination using Pd–dihydroxyterphenylphosphine catalyst. The catalyst accelerates the introduction of the 2-hydroxyphenyl group at the C3 position of the indole.
2,3-disubstituted indoles via palladium-catalyzed reaction of 2-alkynyltrifluoroacetanilides with arenediazonium tetrafluoroborates
Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Perboni, Alcide,Sferrazza, Alessio,Stabile, Paolo
supporting information; experimental part, p. 3279 - 3281 (2010/10/02)
(Figure Presented) A novel palladium-catalyzed synthesis of free N-H 2,3-disubstituted indoles from arenediazonium tetrafluoroborates and 2-alkynyltrifluoroacetanilides is presented. The reaction tolerates a variety of useful substituents both in the starting alkyne and the arenediazonium salt, including bromo and chloro substituents, nitro, cyano, keto, ester, and ether groups, as well as ortho substituents such as methoxy and methyl groups.
