1037299-25-4

Basic information

• Product Name: Trifluoro-methanesulfonic acid (R)-2-((S)-3,3-difluoro-2-oxo-4-phenyl-azetidin-1-yl)-2-phenyl-ethyl ester
• Synonyms: Trifluoro-methanesulfonic acid (R)-2-((S)-3,3-difluoro-2-oxo-4-phenyl-azetidin-1-yl)-2-phenyl-ethyl ester
• CAS NO: 1037299-25-4
• Molecular Weight: 435.371
• Mol File: 1037299-25-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Trifluoro-methanesulfonic acid (R)-2-((S)-3,3-difluoro-2-oxo-4-phenyl-azetidin-1-yl)-2-phenyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Trifluoro-methanesulfonic acid (R)-2-((S)-3,3-difluoro-2-oxo-4-phenyl-azetidin-1-yl)-2-phenyl-ethyl ester(1037299-25-4)
• EPA Substance Registry System: Trifluoro-methanesulfonic acid (R)-2-((S)-3,3-difluoro-2-oxo-4-phenyl-azetidin-1-yl)-2-phenyl-ethyl ester(1037299-25-4)

Safety Data

• Hazardous Substances Data: 1037299-25-4(Hazardous Substances Data)

Upstream product

• 249920-08-9 2,4-diphenyl-1,3-oxazolidine 

Downstream Products

• 252681-18-8 (3S)-3-amino-2,2-difluoro-3-phenylpropanoic acid hydrochloride 
• 252681-07-5 (4S)-3,3-difluoro-4-phenylazetidin-2-one 
• 252681-06-4 (4S)-3,3-difluoro-4-phenyl-1-(1-phenylvinyl)azetidin-2-one 

Relevant articles and documents

Enantioselective synthesis of α,α-difluoro-β-amino acid and 3,3- difluoroazetidin-2-one via the reformatsky-type reaction of ethyl bromodifluoroacetate with chiral 1,3-oxazolidines

Chiral oxazolidines 2a-e can be diastereoselectively alkylated with BrCF2CO2Et to furnish 3,3-difluoroazetidin-2-ones 3a-e with up to 99% de. Selective cleavage of the chiral appendage provided the corresponding unsubstituted azetidinones. Formation of optically pure α,α-difluoro-β- amino acids 5a-c can be achieved by acidic hydrolysis of N-vinyl-azetidin-2- ones.