252681-06-4

Basic information

• Product Name: (4S)-3,3-difluoro-4-phenyl-1-(1-phenylvinyl)azetidin-2-one
• Synonyms: (4S)-3,3-difluoro-4-phenyl-1-(1-phenylvinyl)azetidin-2-one
• CAS NO: 252681-06-4
• Molecular Weight: 285.293
• Mol File: 252681-06-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4S)-3,3-difluoro-4-phenyl-1-(1-phenylvinyl)azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-3,3-difluoro-4-phenyl-1-(1-phenylvinyl)azetidin-2-one(252681-06-4)
• EPA Substance Registry System: (4S)-3,3-difluoro-4-phenyl-1-(1-phenylvinyl)azetidin-2-one(252681-06-4)

Safety Data

• Hazardous Substances Data: 252681-06-4(Hazardous Substances Data)

Upstream product

• 252681-03-1 (4S)-3,3-difluoro-1-((1R)-2-hydroxy-1-phenylethyl)-4-phenylazetidin-2-one 
• 249920-08-9 2,4-diphenyl-1,3-oxazolidine 
• 1037299-25-4 Trifluoro-methanesulfonic acid (R)-2-((S)-3,3-difluoro-2-oxo-4-phenyl-azetidin-1-yl)-2-phenyl-ethyl ester 

Downstream Products

• 252681-18-8 (3S)-3-amino-2,2-difluoro-3-phenylpropanoic acid hydrochloride 
• 252681-07-5 (4S)-3,3-difluoro-4-phenylazetidin-2-one 

Relevant articles and documents

Rhodium-catalyzed Reformatsky-type reaction for asymmetric synthesis of difluoro-β-lactams using menthyl group as a chiral auxiliary

We developed a new methodology for the asymmetric Reformatsky-type reaction of (-)-menthyl bromodifluoroacetate (2) with imine in the presence of RhCl(PPh3)3. Ester 2 with the cost-effective chiral auxiliary gave (S)-difluoro-β-lacta