Asymmetric Transformation of (RS)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid via Salt Formation with (1S)-10-Camphorsulfonic Acid

Article abstract of DOI:10.1246/bcsj.64.3729

Asymmetric transformation of (RS)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid <(RS)-TIC> by use of (1S)-10-camphorsulfonic acid <(S)-CS> as a resolving agent gave a salt of (S)-TIC with (S)-CS with 90percent optical purity in hexanoic acid.The TIC obtained from the salt was purified to give optically pure (S)-TIC in 80percent yield based on the starting (RS)-TIC.