103747-89-3Relevant academic research and scientific papers
Chiral (Macrocyclic) Sulfide- and Sulfide/Alkylamino-Containing Ligands for Nickel-Catalyzed Grignard Cross-Coupling Reactions
Vriesema, Bindert K.,Lemaire, Marc,Buter, Jan,Kellogg, Richard M.
, p. 5169 - 5177 (2007/10/02)
Some macrocycles that contain sulfide and/or amino linkages as coordination sites have been examined as ligands for the nickel-catalyzed cross-coupling of the Grignard reagent of 1-phenyl-1-chloroethane with vinyl vromide to provide (1-methyl-2-propenyl)b
MACROCYCLES WITH SULFIDE AND AMINE BINDING SITES AS CHIRAL LIGANDS FOR NICKEL CATALYZED CROSS COUPLING OF A GRIGNARD REAGENT WITH VINYL BROMIDE
Lemaire, Marc,Vrisema, Bindert K.,Kellogg, Richard M.
, p. 3499 - 3502 (2007/10/02)
Syntethic routes to macrocycles derived from (S)-phenyl alanine and (S)-cysteine have been developed.The catalyzed coupling of the Grignard reagent of 1-chloro-1-phenylethane and vinyl bromide in the presence of these ligands proceeds usually in good yields and in enantiomeric excesse (e.e.) of up to 46percent.
