1037510-80-7Relevant academic research and scientific papers
Cu2+-doped zeolitic imidazolate frameworks (ZIF-8): Efficient and stable catalysts for cycloadditions and condensation reactions
Schejn, Aleksandra,Aboulaich, Abdelhay,Balan, Lavinia,Falk, Véronique,Lalevée, Jacques,Medjahdi, Ghouti,Aranda, Lionel,Mozet, Kevin,Schneider, Rapha?l
, p. 1829 - 1839 (2015)
Cu2+-doped zeolitic imidazolate framework (ZIF) crystals were efficiently prepared by reaction of Cu(NO3)2, Zn(NO3)2, and 2-methylimidazole in methanol at room temperature. Scanning electron microscopy, transmission electron microscopy and X-ray diffraction showed that the Cu/ZIF-8 particles were nanosized (between ca. 120 and 170 nm) and that the body-centered cubic crystal lattice of the parent ZIF-8 framework is continuously maintained, regardless of the doping percentage. Moreover, thermogravimetric analyses and specific BET surface area measurements demonstrated that the doping does not alter the high stability of ZIF-8 crystals and that the porosity only decreases at a high doping percentage (25% in Cu2+). The Cu/ZIF-8 material showed excellent catalytic activity in the [3 + 2] cycloaddition of organic azides with alkynes and in Friedl?nder and Combes condensations due to the high catalyst surface area and the high dispersion of Cu/ZIF-8 particles. Notably, the Cu/ZIF-8 particles not only exhibit excellent performance but also show great stability in the reaction, allowing their reuse up to ten times in condensation reactions. Our findings explored a simple and powerful way to incorporate metal ions into the backbones of open framework materials without losing their properties.
Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group
Chen, Po C.,Patil, Vishal,Guerrant, William,Green, Patience,Oyelere, Adegboyega K.
, p. 4839 - 4853 (2008/12/21)
Histone deacetylase (HDAC) inhibition is a recent, clinically validated therapeutic strategy for cancer treatment. Small molecule HDAC inhibitors identified so far fall in to three distinct structural motifs: the zinc-binding group (ZBG), a hydrophobic linker, and a recognition cap group. Here we report the suitability of a 1,2,3-triazole ring as a surface recognition cap group-linking moiety in suberoylanilide hydroxamic acid-like (SAHA-like) HDAC inhibitors. Using "click" chemistry (Huisgen cycloaddition reaction), several triazole-linked SAHA-like hydroxamates were synthesized. Structure-activity relationship revealed that the position of the triazole moiety as well as the identity of the cap group markedly affected the in vitro HDAC inhibition and cell growth inhibitory activities of this class of compounds.
