103755-53-9Relevant academic research and scientific papers
Synthesis of 2-Substituted 1,2,3-Triazoles via an Intramolecular N–N Bond Formation
Chen, Cheng-yi,Lu, Xiaowei,Holland, Mareike C.,Lv, Shichang,Ji, Xuebao,Liu, Wei,Liu, Jie,Depre, Dominique,Westerduin, Pieter
, p. 548 - 551 (2019/12/24)
An efficient synthesis of 2-aryl 1,2,3-triazoles based on an intramolecular N–N bond formation is described. Selective activation of bis-hydrazone at the dimethylamino hydrazone group with MeI forms a mono-hydrazonium species. Treatment of the hydrazonium
Regioselective ortho-Acylation of N-Aryl-1,2,3-triazoles with Alcohols in Water
Premi, Chanchal,Patel, Shyam Sunder,Jain, Nidhi
, p. 3788 - 3795 (2016/08/16)
A palladium-catalyzed regioselective ortho-acylation of N-aryl-1,2,3-triazoles has been achieved under aqueous conditions without the assistance of surfactants or additives. The reaction takes place by using benzylic, heterocyclic, and aliphatic alcohols as the acylating reagents and tert-butyl hydroperoxide (TBHP) as the oxidant and provides an alternative route for the synthesis of triazole-substituted aryl, heteroaryl, and aliphatic ketones in moderate to excellent yields.
PREPARATION OF A BENZOIC ACID DERIVATIVE AND ITS USE FOR THE PREPARATION OF SUVOREXANT
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Page/Page column 89, (2016/04/04)
The present invention relates to a process for the preparation of a compound of formula (1) wherein the process is based on the use of an organolithium reagent and wherein Ra, Rb, Rc and Rd are, independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl, heterocycloalkyl, halogen, carbonyl, alkoxy, hydroxyl, -NR6R7, -SR and -NO2, wherein R6 and R7 are, independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, and wherein E is an electrophilic group. The present invention further relates as to a compound obtained or obtainable by said method and to a compound of formula (1) as such. Further, the present invention relates to use of the compound of formula (1) for the preparation of Suvorexant.
Palladium-catalyzed ortho-alkoxylation of 2-aryl-1,2,3-triazoles
Shi, Suping,Kuang, Chunxiang
, p. 6105 - 6112 (2014/07/21)
Palladium-catalyzed alkoxylation of 2-aryl-1,2,3-triazoles was described in the presence of various groups in the aromatic rings. In addition, some other directing groups of heterocycles containing nitrogen were explored.
An easy arylation of 2-substituted 1,2,3-triazoles
Shi, Suping,Liu, Wei,He, Ping,Kuang, Chunxiang
supporting information, p. 3576 - 3580 (2014/06/09)
A selective, efficient and catalytic ligand-free method for the direct arylation of 2-aryl-1,2,3-triazoles via Pd-catalyzed C-H bond activation is described. The process smoothly proceeds in moderate to excellent yields. This journal is the Partner Organisations 2014.
Palladium-Catalyzed 2H-1,2,3-Triazole-Directed Oxidative Alkoxylation of Arenes with Alcohols
Shi, Wenjuan,Shi, Zhangjie
supporting information, p. 974 - 980 (2016/02/18)
A palladium catalyzed ortho-alkoxylation of aryl C-H bond was accomplished with primary and secondary alcohols as alkoxylation reagents and with triazole as new directing group. This transformation has a good functional group tolerance and is not sensitive to moisture and air. A palladium catalyzed ortho-alkoxylation of aryl C-H bond with alcohols was described. Trizaole was used as new directing group. A series of functional groups could be tolerated and the reaction is not sensitive to moisture and air.
Regioselective halogenation of 2-substituted-1,2,3-triazoles via sp 2 C-H activation
Tian, Qingshan,Chen, Xianmin,Liu, Wei,Wang, Zechao,Shi, Suping,Kuang, Chunxiang
supporting information, p. 7830 - 7833 (2013/11/19)
A highly regioselective halogenation of 2-substituted-1,2,3-triazoles was developed via sp2 C-H activation. This method is compatible with halogen atoms, as well as electron-donating and electron-withdrawing groups. Meanwhile, the strategy is a
