79762-67-7

Upstream product

• 131543-46-9 Glyoxal 
• 539-44-6 N-4-methylphenylhydrazine 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 35467-65-3 4-methylphenylhydrazine hydrochloride 

Downstream Products

• 956317-36-5 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid 
• 1381980-75-1 2-(2-iodo-4-methylphenyl)-2H-[1,2,3]triazole 
• 1171114-58-1 C₁₆H₂₀N₄O 
• 103755-53-9 2-(4-methylphenyl)-2H-[1,2,3]-triazole 
• 1381980-67-1 4-iodo-2-(4-methylphenyl)-2H-[1,2,3]triazole 
• 1381980-71-7 4-iodo-2-(2-iodo-4-methylphenyl)-2H-[1,2,3]triazole 

Relevant academic research and scientific papers

Regioselective ortho-Acylation of N-Aryl-1,2,3-triazoles with Alcohols in Water

A palladium-catalyzed regioselective ortho-acylation of N-aryl-1,2,3-triazoles has been achieved under aqueous conditions without the assistance of surfactants or additives. The reaction takes place by using benzylic, heterocyclic, and aliphatic alcohols as the acylating reagents and tert-butyl hydroperoxide (TBHP) as the oxidant and provides an alternative route for the synthesis of triazole-substituted aryl, heteroaryl, and aliphatic ketones in moderate to excellent yields.

PREPARATION OF A BENZOIC ACID DERIVATIVE AND ITS USE FOR THE PREPARATION OF SUVOREXANT

The present invention relates to a process for the preparation of a compound of formula (1) wherein the process is based on the use of an organolithium reagent and wherein Ra, Rb, Rc and Rd are, independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl, heterocycloalkyl, halogen, carbonyl, alkoxy, hydroxyl, -NR6R7, -SR and -NO2, wherein R6 and R7 are, independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, and wherein E is an electrophilic group. The present invention further relates as to a compound obtained or obtainable by said method and to a compound of formula (1) as such. Further, the present invention relates to use of the compound of formula (1) for the preparation of Suvorexant.

Deproto-metallation and computed CH acidity of 2-aryl-1,2,3-triazoles

2-Aryl-1,2,3-triazoles were synthesized by cyclization of the corresponding glyoxal arylosazones, generated from commercial arylhydrazines. The deproto-metallation of 2-phenyl-1,2,3-triazole was attempted using different 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal (Zn, Cd, Cu, Co, Fe) combinations, giving results in the case of Zn, Cd, and Cu. The lithium-zinc combination was next selected to apply the deprotonation-iodination sequence to all the 2-aryl-1,2,3-triazoles synthesized. The results were analyzed with the help of the CH acidities of the substrates, determined in THF solution using the DFT B3LYP method.