1425058-79-2

Upstream product

• 15757-32-1 3-hydroxy-1-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one 
• 545-06-2 trichloroacetonitrile 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1037586-64-3 1-methyl-3-morpholin-4-yl-3-phenyl-1,3-dihydroindol-2-one 
• 42773-97-7 (±)-3-methoxy-1-methyl-3-phenylindolin-2-one 
• 1425058-54-3 3-(1H-indol-3-yl)-1-methyl-3-phenylindolin-2-one 
• 1425058-55-4 1-methyl-3-phenyl-3-(1H-pyrrol-2-yl)indolin-2-one 
• 1425058-56-5 3-(4-hydroxyphenyl)-1-methyl-3-phenylindolin-2-one 
• 1315281-16-3 3-(5-(tert-butyl)-2-hydroxyphenyl)-1-methyl-3-phenylindolin-2-one 
• 1425058-59-8 1-methyl-3-phenyl-3-(phenylamino)indolin-2-one 
• 1425058-61-2 3-(3,4-dihydro-2H-pyran-5-yl)-1-methyl-3-phenylindolin-2-one 

Relevant academic research and scientific papers

Synthesis of 3,3-disubstituted oxindoles by one-pot integrated Br?nsted base-catalyzed trichloroacetimidation of 3-hydroxyoxindoles and Br?nsted acid-catalyzed nucleophilic substitution reaction

Treatment of 3-hydroxyoxindoles with trichloroacetonitrile (1.3 equiv.) and a catalytic amount of DBU (0.1 equiv.) followed by addition of nucleophiles (1.5 equiv.) and diphenylphosphoric acid (0.2 equiv.) afforded the 3,3-disubstituted oxindoles in good to excellent yields. DFT computations supported the notion that the reaction went through the 1-alkyl-2-oxo-2H-indol- 1-ium intermediate.