103763-39-9

Upstream product

• 96-48-0 4-butanolide 
• 103781-89-1 6-benzyloxy-1H-indole-2-carboxylic acid methyl ester 
• 4397-53-9 p-benzyloxybenzaldehyde 

Downstream Products

• 103763-46-8 1-(6-benzyloxyindol-2-yl)butane-1,4-dione 
• 103763-36-6 7-benzyloxy-1-methoxy-9H-carbazole 
• 115663-20-2 1-(6-benzyloxyindol-2-yl)-4-hydroxy-2-methylbutan-1-one 
• 115663-19-9 3-(6-benzyloxyindol-2-ylcarbonyl)-4,5-dihydro-3-methylfuran-2-one 
• 103763-42-4 4-hydroxy-1-(6-benzyloxyindol-2-yl)butan-1-one 

Relevant academic research and scientific papers

A NEW ROUTE TO 1-OXYGENATED CARBAZOLES. SYNTHESIS OF MURRAYAFOLINE-A

1-Oxygenated carbazoles are prepared in four steps from indole-2-carboxylates by Claisen condensation with butyrolactones, followed by hydrolysis with concomitant decarboxylation, oxidation, and ring closure (Scheme 2); the route is applied to the synthes

A NEW ROUTE TO 1-OXYGENATED CARBAZOLES. SYNTHESIS OF THE CARBAZOLE ALKALOIDS MURRAYAFOLINE-A AND MURRAYAQUINONE-A

1-Oxygenated carbazoles are prepared in 4 steps from indole-2-carboxylates by condensation with γ-butyrolactones to give the lactones (12), followed by hydrolysis with concomitant decarboxylation to the alcohols (13), and oxidation to the aldehydes (14).The aldehydes (14) cyclise to 1-methoxycarbazoles on treatment with boron trifluoride-methanol or with methanolic hydrogen chloride.The methoxycarbazoles (15a) and (4) were converted into the corresponding carbazolequinones (18) and (7) by demethylation, and oxidation.The carbazole alkaloids murrayafoline-A (4) and murrayaquinone-A (7) were prepared.