103768-05-4Relevant articles and documents
An easy access to homopropargylic ethers
Guedin-Vuong, Denis,Nakatani, Yoichi
, p. 245 - 252 (2007/10/02)
Chloromethyl ethers, obtained from alcohols, formaldehyde and HCl, react regioselectively, as shown previously in one case by L.Miginiac, with allenyl aluminium reagents derived from propargyl bromides and aluminium, to give homopropargyl ethers.No evidence for the presence of allenyl ethers was obtained in the cases described.This condensation is used to obtain a protected acetylenic synthon 1, required for the synthesis of an ecdysteroid analogue (1).
SYNTHESIS OF C27-SUBSTITUTED ECDYSTEROIDS, POTENTIAL TOOLS FOR BIOCHEMICAL STUDIES
Guedin-Vuong, D.,Nakatani, Y.,Luu, B.,Ourisson, G.
, p. 5959 - 5962 (2007/10/02)
A sequence of selective protection procedures is described, facilitating the efficient cleavage of the ecdysteroid side-chain, which can then be reconstructed; in this way, C-27 ether-linked analogues of ecdysteroids have been synthesized, one of which di