61440-45-7

Basic information

• Product Name: 3-[4-(BENZYLOXY)PHENYL]-1-PROPANOL
• Synonyms: 3-[4-(BENZYLOXY)PHENYL]-1-PROPANOL;3-(4-(benzyloxy)phenyl)propan-1-ol
• CAS NO: 61440-45-7
• Molecular Formula: C₁₆H₁₈O₂
• Molecular Weight: 242.31
• Mol File: 61440-45-7.mol
• Article Data: 39

Chemical Properties

• Melting Point: 58-61°C
• Boiling Point: 400.3°C at 760 mmHg
• Flash Point: 179.8°C
• Appearance: /
• Density: 1.096g/cm³
• Vapor Pressure: 3.97E-07mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 3-[4-(BENZYLOXY)PHENYL]-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(BENZYLOXY)PHENYL]-1-PROPANOL(61440-45-7)
• EPA Substance Registry System: 3-[4-(BENZYLOXY)PHENYL]-1-PROPANOL(61440-45-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61440-45-7(Hazardous Substances Data)

Usage

General Description

3-[4-(benzyloxy)phenyl]-1-propanol is a chemical compound that belongs to the family of alcohols. Its chemical structure consists of a benzene ring attached to a propyl group, with a benzyloxy group substituting one of the hydrogen atoms on the benzene ring. 3-[4-(BENZYLOXY)PHENYL]-1-PROPANOL is commonly used in organic synthesis and as a building block for the production of pharmaceuticals, dyes, and other fine chemicals. It has properties that make it useful as a solvent, a reagent in chemical reactions, and as a key intermediate in the synthesis of various products. Additionally, it is important to handle this chemical with caution, as it may have potential hazards if not used properly.

InChI:InChI=1/C16H18O2/c17-12-4-7-14-8-10-16(11-9-14)18-13-15-5-2-1-3-6-15/h1-3,5-6,8-11,17H,4,7,12-13H2

Upstream product

• 58608-97-2 3-(4-benzyloxyphenyl)propionic acid benzyl ester 
• 10210-17-0 3-(4-hydroxyphenyl)propan-1-ol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 836-42-0 4-benzyloxybenzyl chloride 
• 104315-07-3 (E)-ethyl 3-(4-(benzyloxy)phenyl)acrylate 
• 68486-77-1 3-(4-(benzyloxy)phenyl)propanal 
• 68486-76-0 4-(2-benzyloxy-3,4-dimethoxyphenyl)-1-bromobutane 
• 186895-45-4 ethyl 3-(4-(benzyloxy)phenyl)propanoate 
• 50463-48-4 3-(4-benzyloxyphenyl)propanoic acid 
• 24807-40-7 methyl 3-(4-benzyloxyphenyl)propanoate 
• 6272-45-3 4-benzyloxycinnamic acid 
• 90617-59-7 1-(benzyloxy)-4-(prop-2-en-1-yl)benzene 
• 501-92-8 4-(prop-2-enyl)phenol 

Downstream Products

• 104211-82-7 1-Benzyloxy-4-(3-chloromethoxy-propyl)-benzene 
• 141361-43-5 3-(4-Benzyloxyphenyl)propyl tetracosanoate 
• 99203-73-3 3-(4-(benzyloxy)phenyl)propyl 4-methylbenzenesulfonate 
• 868992-17-0 O-[3-(4-phenylmethoxyphenyl)-1-propyl]-(2,3,4,6-O-tetraacetyl)-β-D-galacto-pyranose 
• 103768-07-6 4-[3-(2-Methyl-but-3-ynyloxy)-propyl]-phenol 
• 103768-05-4 1-(1-Ethoxy-ethoxy)-4-[3-(2-methyl-but-3-ynyloxy)-propyl]-benzene 
• 107114-16-9 1-Benzyloxy-4-(3-but-3-ynyloxy-propyl)-benzene 
• 61440-41-3 1-benzyloxy-4-[3-(methanesulphonyloxy)propyl]-benzene 
• 1338496-32-4 3-(4-benzyloxyphenyl)propyl 2-acetamido-2-deoxy-β-D-glucopyranoside 
• 1338496-35-7 3-(4-hydroxyphenyl)propyl 2-acetamido-2-deoxy-β-D-glucopyranoside 
• 1338496-23-3 C₃₀H₃₇NO₁₀ 
• 1251830-59-7 4,4'-[(1E,5R)-5-hydroxyhept-1-ene-1,7-diyl]diphenol 
• 134721-17-8 1-(benzyloxy)-4-(but-3-en-1-yl)benzene 
• 79407-40-2 2-{2-[4-(benzyloxy)phenyl]ethyl}oxirane 

Relevant articles and documents

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Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-molecule drugs capable of inducing it at the clinical level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and druggable angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and nondiabetic HLI mice. Together, this study offers a novel, promising small-molecule-based therapeutic strategy for treating HLI.

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